Correlation of Platelet-To-Lymphocyte Ratio and Neutrophil-To-Lymphocyte Ratio With Thrombolysis in Myocardial Infarction Frame Count in St-Segment Elevation Myocardial Infarction Publisher Pubmed



Vakili H¹ ; Shirazi M¹ ; Charkhkar M¹ ; Khaheshi I¹ ; Memaryan M¹ ; Naderian M^{2, 3}
Source: European Journal of Clinical Investigation Published:2017

Abstract

Background: Impaired coronary artery reflow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated with postintervention adverse effects. Thus, finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been introduced. In this study, we aimed to investigate correlation of PLR and NLR with thrombolysis in myocardial infarction (TIMI) frame count. Materials and methods: A total of 215 consecutive patients with ST-segment elevation myocardial infarction (STEMI) were recruited. Pre-intervention laboratory tests were performed. Moreover, PLR and NLR were calculated for each patient. Ultimately, TIMI frame count was assessed subsequent to primary PCI for each patient. Results: We found that both PLR and NLR are correlated with TIMI frame count (R: 0·372, P < 0·001 and R: 0·301, P < 0·001, respectively). Furthermore, it was revealed that both PLR and NLR are positively correlated with corrected TIMI frame count (R: 0·388, P < 0·001 and R: 0·290, P < 0·001, respectively). Conclusions: PLR and NLR are two easily calculated and efficient indexes for predicting the no-reflow phenomenon in patients with STEMI undergoing PPCI. Therefore, they might be employed in accurate risk stratification when a patient is a candidate for PPCI and in accurately referring patients who would benefit greatly from PPCI. © 2017 Stichting European Society for Clinical Investigation Journal Foundation