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Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems Publisher



Moghimi S1 ; Goligarmroodi F1 ; Pilali H1 ; Mahdavi M2 ; Firoozpour L2 ; Nadri H3 ; Moradi A3 ; Asadipour A4 ; Shafiee A1 ; Foroumadi A1, 4
Authors

Source: Journal of Chemical Sciences Published:2016


Abstract

An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method. [Figure not available: see fulltext.] © 2016, Indian Academy of Sciences.
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