Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Interferons: Role in Cancer Therapy Publisher Pubmed



Abdolvahab MH1 ; Darvishi B1 ; Zarei M2, 3 ; Majidzadeha K1 ; Farahmand L1
Authors

Source: Immunotherapy Published:2020


Abstract

Interferons (IFNs) are a group of signaling cytokines, secreted by host cells to induce protection against various disorders. IFNs can directly impact on tumor cells or indirectly induce the immune system to protect host cells. The expression levels of IFNs and its functions of are excellently modulated in a way to protect host cells from probable toxicities caused by extreme responses. The efficacy of anticancer therapies is correlated to IFNs signaling. Although IFN signaling is involved in induction of antitumor responses, chronic stimulation of the IFN signaling pathway can induce resistance to various antineoplasm therapies. Hence, IFNs are expressed by both cancer and immune cells, and modulate their biological function. Understanding this mechanism of action might be a key target of combination therapies. © 2020 Future Medicine Ltd.
Related Docs
View other Related Docs
1. Tumor Immunology, Clinical Immunology (2022)
2. Review on Interferon Beta: From Cells to Clinical Usage, Koomesh (2022)
3. Immunotherapy of Cancers Comes of Age, Expert Review of Clinical Immunology (2017)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (9)
Fereydon Memari (1)
Other Related Docs
4. Hurdles in Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
5. How Micrornas Affect the Pd-L1 and Its Synthetic Pathway in Cancer, International Immunopharmacology (2020)
6. The Role of Interferon-Gamma and Its Receptors in Gastrointestinal Cancers, Pathology Research and Practice (2023)
7. Immunotherapy a New Hope for Cancer Treatment: A Review, Pakistan Journal of Biological Sciences (2018)
8. Next-Generation Version of Recombinant Human Interferon-Beta: A Molecular Dynamic Simulation Study, Informatics in Medicine Unlocked (2022)
9. Implications of Toll-Like Receptors in Ebola Infection, Expert Opinion on Therapeutic Targets (2017)
10. Resistance to Immunotherapy in Human Malignancies: Mechanisms, Research Progresses, Challenges, and Opportunities, Journal of Cellular Physiology (2022)
11. Nano-Immunotherapy: Overcoming Delivery Challenge of Immune Checkpoint Therapy, Journal of Nanobiotechnology (2023)
12. Pd-1/Pd-L1 Pathway: Basic Biology and Role in Cancer Immunotherapy, Journal of Cellular Physiology (2019)
13. Immunotherapeutic Approaches in Cancer, Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives (2019)
14. Immunotherapeutic Approaches in Cancer, Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives (2018)
15. Looking for Biomarkers in Interferon Response Pathway to Predict Response to Oncolytic Hsv-1 in Breast Cancer: An Ex Vivo Study, Cancer Biomarkers (2023)
16. The Promising Role of Monoclonal Antibodies for Gastric Cancer Treatment, Immunotherapy (2019)
17. Resistance Mechanisms to Programmed Cell Death Protein 1 and Programmed Death Ligand 1 Inhibitors, Expert Opinion on Biological Therapy (2021)
18. The Role of Dendritic Cells in Neuroblastoma: Implications for Immunotherapy, Immunobiology (2022)
19. Immune Landscape of Hepatocellular Carcinoma: From Dysregulation of the Immune Responses to the Potential Immunotherapies, Cell Biochemistry and Function (2024)
20. Clinical Potential of Pd-1/Pd-L1 Blockade Therapy for Renal Cell Carcinoma (Rcc): A Rapidly Evolving Strategy, Cancer Cell International (2022)