The Role of Alpha-Synuclein in Neurodevelopmental Diseases Publisher Pubmed



Bordbar S^{1, 2} ; Alijanzadeh D^{2, 3, 4} ; Samieefar N^{2, 3, 4} ; Khazeei Tabari MA^{2, 5, 6} ; Pourbakhtyaran E^{2, 3, 7} ; Rezaei N^{2, 8, 9}
Source: Molecular Neurobiology Published:2025

Abstract

Neurodevelopmental disorders are a group of diseases with cognitive, motor, and emotional development deficits. Alpha-synuclein (α-syn) is a synaptic protein involved in transmission and neurodevelopment. This protein was previously shown to be associated with several disorders, including Parkinson’s disease. Furthermore, a close link between neurodevelopmental disorders and Parkinson’s has also been found. Changes in synaptic function have been noticed in neurodevelopmental disorders, including autism spectrum disorder. Impaired neurogenesis and related cognitive problems have been associated with altered expression of α-syn. Various studies reported α-syn in different body fluids and tissues such as blood and serum. Alpha-synuclein can help in better understanding the pathogenesis of neurodevelopmental diseases and facilitating their early diagnosis. This review aims to go over the recent advances in the role of α-syn in the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, and motor and social impairment, and its value as a diagnostic biomarker. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.