Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer

Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer

Talebzadeh M ; Eshkiki Z S ; Masoodi M ; Agah S ; Namazi A ; Tabaeian S P ; Beigi S N ; Ali S B ; Akbari A

Source: Govaresh Published:2026

Abstract

Background: Long non-coding RNAs (lncRNAs) have more and more investigated as novel and valuable biomarkers in cancers. We aimed to examine the expression and potential diagnostic value of two oncogenic lncRNAs, MALAT-1 and ROR, in tumor-educated platelets (TEPs) of patients with colorectal cancer (CRC). Materials and Methods: The expression levels of TEP lncRNAs were analyzed in 68 patients with CRC and 68 healthy individuals by a quantitative real-time PCR (qPCR). The differential expression of lncRNAs was examined, and diagnostic values were obtained. Results: TEP lncRNA MALAT-1 expression levels were significantly increased (P=0.044) in patients with CRC compared to healthy individuals. The expression levels of lncRNA ROR did not show a significant change (P=0.672) between patients with CRC and healthy individuals. Moreover, a significant correlation between MALAT-1 and tumor differentiation and lymphovascular invasion (P<0.05) was detected. TEP lncRNA MALAT-1 showed a diagnostic potential by sensitivity 63% and specificity 66% with AUC 0.66. Conclusion: LncRNA MALAT-1 is upregulated in TEPs from patients with CRC and has potential clinical value as a cancer biomarker. © (2026), (Iranian Association of Gastroenterology and Hepatology). All rights reserved.

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Style	Citing Format
MLA	Talebzadeh M, et al.. "Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer." Govaresh, vol. 30, no. 4, 2026, pp. 217-222.
APA	Talebzadeh M, Eshkiki Z S, Masoodi M, Agah S, Namazi A, Tabaeian S P, Beigi S N, Ali S B, Akbari A (2026). Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer. Govaresh, 30(4), 217-222.
Chicago	Talebzadeh M, Eshkiki Z S, Masoodi M, Agah S, Namazi A, Tabaeian S P, Beigi S N, Ali S B, Akbari A. "Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer." Govaresh 30, no. 4 (2026): 217-222.
Harvard	Talebzadeh M et al. (2026) 'Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer', Govaresh, 30(4), pp. 217-222.
Vancouver	Talebzadeh M, Eshkiki Z S, Masoodi M, Agah S, Namazi A, Tabaeian S P, et al.. Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer. Govaresh. 2026;30(4):217-222.
BibTex	@article{ author = {Talebzadeh M and Eshkiki Z S and Masoodi M and Agah S and Namazi A and Tabaeian S P and Beigi S N and Ali S B and Akbari A}, title = {Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer}, journal = {Govaresh}, volume = {30}, number = {4}, pages = {217-222}, year = {2026} }
RIS	TY - JOUR AU - Talebzadeh M AU - Eshkiki Z S AU - Masoodi M AU - Agah S AU - Namazi A AU - Tabaeian S P AU - Beigi S N AU - Ali S B AU - Akbari A TI - Tumor-Educated Platelet Lncrna Malat-1; Expression Levels and Clinical Potential As a Biomarker in Colorectal Cancer JO - Govaresh VL - 30 IS - 4 SP - 217 EP - 222 PY - 2026 ER -

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