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Recurrent Membranous Nephropathy Management After Kidney Transplant, Case Report



Forghani MS1 ; Rahimzadeh H2 ; Parvin M3 ; Mohammadi A1
Authors

Source: Scientific Journal of Kurdistan University of Medical Sciences Published:2023

Abstract

Background and Aim: Membranous nephropathy (MN) is a podocytopathy characterized histologically by uniform thickening of the glomerular basement membrane due to the presence of subepithelial immune deposition. This disease can occur in a transplanted kidney as a recurrence of primary (Recurrent Membranous Nephropathy, RMN) or de novo disease. Case report: A 40-year-old non-smoker man with a history of membranous nephropathy and kidney failure due to it, underwent a kidney biopsy 9 months after transplantation because of proteinuria of 4000 mg/day, and with the diagnosis of recurrence of membranous nephropathy in the transplanted kidney, he was given two doses of Rituximab 1000 mg with 15 days’ interval. Gradually, the amount of proteinuria decreased and reached 188 mg/day after 4 months, and his kidney function remained stable (creatinine 0.8 mg/dl) during the treatment. Conclusion: Membranous nephropathy can recur after kidney transplantation, in cases of proteinuria more than one gram per day, Rituximab can be used. © 2018 the Author (s).
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