Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Association of Mir-149 (Rs2292832) Variant With the Risk of Coronary Artery Disease Publisher



Ghaffarzadeh M1 ; Ghaedi H1 ; Alipoor B2 ; Omrani MD3 ; Kazerouni F1 ; Shanaki M1 ; Labbaf A1 ; Pashaiefar H4 ; Rahimipour A1
Authors

Source: Journal of Medical Biochemistry Published:2017


Abstract

Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP rs2292832 and the risk of CAD in an Iranian population. Methods: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls). Results: Our analysis revealed that the TT genotype was more frequent in CAD patients than control subjects (P=0.02) implying that TT genotype should be considered as a risk factor in CAD development (TT vs. TC+CC p=0.02, OR=1.88). Conclusions: The present study suggests that rs2292832-TT in pre-miR-149 is associated with CAD in an Iranian population. © 2017 Maryam Ghaffarzadeh et al.
Related Docs
View other Related Docs
1. Mirna-Related Polymorphisms in Mir-146A and Tcf21 Are Associated With Increased Susceptibility to Coronary Artery Disease in an Iranian Population, Genetic Testing and Molecular Biomarkers (2016)
2. The Pre-Mir-499 Variant Rs3746444 May Contribute to Coronary Artery Disease Susceptibility: A Case-Control and Meta-Analysis Study, Clinical Laboratory (2017)
3. The Rs2910164 Variant Is Associated With Reduced Mir-146A Expression But Not Cytokine Levels in Patients With Type 2 Diabetes, Journal of Endocrinological Investigation (2018)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Boroumand (4)
Saeed Sadeghian (2)
Other Related Docs
4. Mirna-Related Polymorphisms in Mir-423 (Rs6505162) and Pex6 (Rs1129186) and Risk of Esophageal Squamous Cell Carcinoma in an Iranian Cohort, Genetic Testing and Molecular Biomarkers (2017)
5. Haplotypic Variants of Covid-19 Related Genes Are Associated With Blood Pressure and Metabolites Levels, Journal of Medical Virology (2023)
6. In Silico Dissection of Mirna Targetome Polymorphisms and Their Role in Regulating Mirna-Mediated Gene Expression in Esophageal Cancer, Cell Biochemistry and Biophysics (2016)
7. Bioinformatics Prioritization of Snps Perturbing Microrna Regulation of Hematological Malignancy-Implicated Genes, Genomics (2015)
8. Micrornas As the Actors in the Atherosclerosis Scenario, Journal of Physiology and Biochemistry (2020)
9. Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: A Case-Control Study, Journal of Medical Biochemistry (2017)
10. Plasma Mir-126 Levels and Its Genomic Polymorphism Snp Rs4636297 in Type 2 Diabetes, Asia-Pacific Journal of Molecular Biology and Biotechnology (2020)
11. Association Between Mirna-152 Polymorphism and Risk of Preeclampsia Susceptibility, Archives of Gynecology and Obstetrics (2019)
12. Contribution of Genetic Variants in the Development of Familial Premature Coronary Artery Disease in a Cohort of Cardiac Patients, Clinical Genetics (2024)
13. Circulating Mirna-106B-5P As a Potential Biomarker for Coronary Artery Disease, International Journal of Molecular and Cellular Medicine (2024)
14. The Impact of Vascular Endothelial Growth Factor +405 C/G Polymorphism on Long-Term Outcome and Severity of Coronary Artery Disease, Journal of Clinical Laboratory Analysis (2017)
15. Evaluating the Association of Common Ube2z Variants With Coronary Artery Disease in an Iranian Population, Cellular and Molecular Biology (2015)
16. Association of Increased Levels of Lncrna H19 in Pbmcs With Risk of Coronary Artery Disease, Cell Journal (2019)
17. Association Between Rs10757274 and Rs2383206 Snps As Genetic Risk Factors in Iranian Patients With Coronary Artery Disease, Journal of Tehran University Heart Center (2017)
18. Predictive Inflammation-Related Micrornas for Cardiovascular Events Following Early-Onset Coronary Artery Disease, Archives of Medical Research (2021)
19. The Sdf1 A/G Gene Variant: A Susceptibility Variant for Myocardial Infarction, Genetic Testing and Molecular Biomarkers (2017)
20. Differentially Expressed Mir-152, a Potential Biomarker for In-Stent Restenosis (Isr) in Peripheral Blood Mononuclear Cells (Pbmcs) of Coronary Artery Disease (Cad) Patients, Nutrition# Metabolism and Cardiovascular Diseases (2021)