Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease

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Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease Publisher Pubmed

Asadi M¹ ; Ebrahimi M¹ ; Mohammadikhanaposhtani M² ; Azizian H³ ; Sepehri S⁴ ; Nadri H⁵ ; Biglar M⁶ ; Amanlou M¹ ; Larijani B⁶ ; Mirzazadeh R⁷ ; Edraki N⁸ ; Mahdavi M⁶

Source: Chemistry and Biodiversity Published:2019

Abstract

A novel series of phthalimide-dithiocarbamate hybrids was synthesized and evaluated for in vitro inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The anti-cholinesterase results indicated that among the synthesized compounds, the compounds 7g and 7h showed the most potent anti-AChE and anti-BuChE activities, respectively. Molecular docking and dynamic studies of the compounds 7g and 7h, respectively, in the active site of AChE and BuChE revealed that these compounds as well interacted with studied cholinesterases. These compounds also possessed drug-like properties and were able to cross the BBB. © 2019 Wiley-VHCA AG, Zurich, Switzerland

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Style	Citing Format
MLA	Asadi M, et al.. "Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease." Chemistry and Biodiversity, vol. 16, no. 11, 2019, pp. -.
APA	Asadi M, Ebrahimi M, Mohammadikhanaposhtani M, Azizian H, Sepehri S, Nadri H, Biglar M, Amanlou M, Larijani B, Mirzazadeh R, Edraki N, Mahdavi M (2019). Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease. Chemistry and Biodiversity, 16(11), -.
Chicago	Asadi M, Ebrahimi M, Mohammadikhanaposhtani M, Azizian H, Sepehri S, Nadri H, Biglar M, et al.. "Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease." Chemistry and Biodiversity 16, no. 11 (2019): -.
Harvard	Asadi M et al. (2019) 'Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease', Chemistry and Biodiversity, 16(11), pp. -.
Vancouver	Asadi M, Ebrahimi M, Mohammadikhanaposhtani M, Azizian H, Sepehri S, Nadri H, et al.. Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease. Chemistry and Biodiversity. 2019;16(11):-.
BibTex	@article{ author = {Asadi M and Ebrahimi M and Mohammadikhanaposhtani M and Azizian H and Sepehri S and Nadri H and Biglar M and Amanlou M and Larijani B and Mirzazadeh R and Edraki N and Mahdavi M}, title = {Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease}, journal = {Chemistry and Biodiversity}, volume = {16}, number = {11}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Asadi M AU - Ebrahimi M AU - Mohammadikhanaposhtani M AU - Azizian H AU - Sepehri S AU - Nadri H AU - Biglar M AU - Amanlou M AU - Larijani B AU - Mirzazadeh R AU - Edraki N AU - Mahdavi M TI - Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease JO - Chemistry and Biodiversity VL - 16 IS - 11 SP - EP - PY - 2019 ER -

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