The Relationship Between Visfatin and Serum Concentrations of C-Reactive Protein, Interleukin 6 in Patients With Metabolic Syndrome Publisher Pubmed



Hosseinzadehattar MJ¹ ; Golpaie A² ; Foroughi M² ; Hosseinpanah F³ ; Zahediasl S⁴ ; Azizi F⁵
Source: Journal of Endocrinological Investigation Published:2016

Abstract

Aim: To evaluate the relationship between inflammatory and pro inflammatory markers, with obesity and visceral adiposity in male subjects with or without metabolic syndrome (MS). Subjects and methods: A total of 37 patients with MS and 37 age matched controls were included (mean age 46.35 ± 1.6 years). MS was defined by the criteria of the international diabetes federation 2005. Anthropometric and biochemical profiles, including high-sensitivity C-reactive protein (Hs-CRP), visfatin and interleukin 6 (IL-6), were measured. Data were compared between groups by using t test. Pearson’s correlation was used to evaluate the relationship between variables. P values less than 0.05 were considered as statistically significant. Results: In patients with MS, CRP and IL-6 were significantly correlated with body mass index, waist circumference and waist to hip ratio. Visfatin levels were significantly lower in patients with MS compared to controls (log visfatin: 1.74 ± 0.27 vs. 1.86 ± 0.13 ng/ml, MS vs. control group respectively). We cannot find any significant correlation between visfatin, CRP and IL-6. Also there were no correlation between visfatin levels and any anthropometric parameters in patients with MS or control groups. Conclusion: Serum visfatin was lower in patients with MS. Therefore it seems that visfatin could not be considered as a pro inflammatory adipocytokine in MS. The positive associations of obesity and visceral adiposity with elevated CRP and IL-6 levels suggest the importance of reducing visceral adiposity to prevent the risk of coronary disease. © 2016, Italian Society of Endocrinology (SIE).