C/Ebp Homologous Protein Investigation in the Serum and Cerebro-Spinal Fluid of Relapsing-Remitting Multiple Sclerosis Patients Publisher Pubmed



Karami M¹ ; Aleagha MSE² ; Seidkhaninahal A³ ; Bakhtiyari S³ ; Noorizadeh A³ ; Harirchian MH⁴ ; Siroos B⁴ ; Balood M¹ ; Khosravi A⁵
Source: Journal of Clinical Neuroscience Published:2019

Abstract

The exact determination of endoplasmic reticulum (ER) stress-associated proteins is not completely elucidated in the multiple sclerosis (MS) patients. We measured CHOP concentrations in the serum and cerebro-spinal fluid (CSF) of relapsing-remitting MS (RRMS) patients (n = 20) in comparison with the non-MS control group (n = 20) to determine whether this marker could be detected in the body fluids of RRMS patients. CHOP marker was not detectable in all harvested CSF samples. However, its levels were detectable in all serums harvested from both non-MS and RRMS patients and its levels in the latter group were not significantly higher than those of the non-MS control group (P value = 0.265). CHOP was not detectable in the CSF of RRMS patients in spite of the recent reports on the RRMS autopsies. Additionally, there were not any significant correlations (Spearman's correlation) between both of EDSS score and age with CHOP serum concentrations in all subjects. © 2018 Elsevier Ltd