Polydopamine Biomaterials for Skin Regeneration Publisher Pubmed



Yazdi MK¹ ; Zare M² ; Khodadadi A³ ; Seidi F¹ ; Sajadi SM^{4, 5} ; Zarrintaj P⁶ ; Arefi A⁷ ; Saeb MR⁸ ; Mozafari M⁹
Source: ACS Biomaterials Science and Engineering Published:2022

Abstract

Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of biomedical applications. Moreover, biomaterials based on PDA and its derivatives have near-infrared (NIR) absorption, excellent biocompatibility, intrinsic antioxidative activity, antibacterial activity, and cell affinity. PDA can regulate cell behavior by controlling signal transduction pathways. It governs the focal adhesion behavior of cells at the biomaterials interface. These features make melanin-like PDA a fascinating biomaterial for wound healing and skin regeneration. This paper overviews PDA-based biomaterials' synthesis, properties, and interactions with biological entities. Furthermore, the utilization of PDA nano- and microstructures as a constituent of wound-dressing formulations is highlighted. © 2022 American Chemical Society.