Necrobiotic Xanthogranuloma After Penicillin Injection: A Case Report



Esmaeli N^{1, 2} ; Ghanadan A³ ; Mansouri P⁴ ; Ghaedi F¹
Source: Iranian Journal of Dermatology Published:2017

Abstract

Necrobiotic xanthogranuloma (NXG) is a rare, progressive, non-Langerhans cell histiocytosis characterized by multiple yellowish indurated plaques and subcutaneous nodules that frequently involve the face, trunk, and extremities. Extracutaneous manifestations and paraproteinemia are common. Here, we report the case of a 47-year-old female who referred to the Dermatology Clinic of Razi Hospital, Tehran, Iran with complaints of a yellowish swelling on her right buttock after an intramuscular injection of penicillin. A similar lesion gradually developed on her supraorbital areas after several months. Histopathological findings included granulomatous inflammation of subdermal tissue with necrobiotic foci, which confirmed the diagnosis of NXG. The patient was treated with an intralesional injection of triamcinolone and oral prednisolone. After 12 months of treatment, the plaques became considerably flatter and smaller. © 2017 Iranian Society of Dermatology.