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Distinct Predictors of Post-Thrombotic Symptoms, Signs, and Ulcers After a First Episode Deep Vein Thrombosis: A Riete Registry Study Publisher Pubmed



Parra Caballero P ; Galanaud J P ; Prandoni P ; Jenab Y ; Demelo Rodriguez P ; Otalora S ; Salgueiro Origlia G G ; Gil Diaz A ; Pedrajas J M ; Monreal M ; Brenner B ; Farge Bancel D ; Barba R ; Verhamme P Show All Authors
Authors
  1. Parra Caballero P
  2. Galanaud J P
  3. Prandoni P
  4. Jenab Y
  5. Demelo Rodriguez P
  6. Otalora S
  7. Salgueiro Origlia G G
  8. Gil Diaz A
  9. Pedrajas J M
  10. Monreal M
  11. Brenner B
  12. Farge Bancel D
  13. Barba R
  14. Verhamme P
  15. Yoo H H B
  16. Maly R
  17. Bertoletti L
  18. Schellong S
  19. Tzoran I
  20. Di Micco P
  21. Reis A
  22. Bosevski M
  23. Mazzolai L
  24. Caprini J A
  25. Bui M H
  26. Abad Fernandez A
  27. Adarraga M D
  28. Aibar J
  29. Alda A
  30. Alfonso J
  31. Amado C
  32. Bascunana J
  33. Angelina Garcia M
  34. Arcelus J I
  35. Ballaz A
  36. Barbagelata C
  37. Barron M
  38. Barron Andres B
  39. Beddar Chaib F
  40. Bencosme De Mendez E I
  41. Blanco Molina A
  42. Chamorro N
  43. Chasco L
  44. Claver G
  45. Crecente P
  46. Criado J
  47. De Ancos Aracil C
  48. De Juana Izquierdo C
  49. Del Toro J
  50. Diaz Pedroche M C
  51. Diaz Peromingo J A
  52. Dubois Silva A
  53. Duran D
  54. Escribano J C
  55. Farfan Sedado A I
  56. Fernandez Bermejo L A
  57. Fernandez Martinez De Septien C
  58. Fernandez Reyes J L
  59. Fernandez Capitan C
  60. Fidalgo M
  61. Gabara C
  62. Garcia Ortega A
  63. Gavin Sebastian O
  64. Gomez Cuervo C
  65. Gorostidi Perez J
  66. Guirado L
  67. Gutierrez Guisado J
  68. Hernandez Blasco L
  69. Hernandez Borge J
  70. Huelamo Lopez P
  71. Jimenez D
  72. Joya M D
  73. Lecumberri R
  74. Llamas P
  75. Lopez Jimenez L
  76. Lopez Miguel P
  77. Lopez Nunez J J
  78. Lopez Rubio M
  79. Lopez Ruiz A
  80. Lopez Saez J B
  81. Madronal Cerezo E
  82. Maestre A
  83. Marchena P J
  84. Marcos M
  85. Marin Baselga R
  86. Martin Del Pozo M
  87. Menendez Sanchez C
  88. Mercado M I
  89. Moises Lafuente J
  90. Monzon Escribano L
  91. Moreno Casas S
  92. Navas M S
  93. Nieto J A
  94. Nunez Fernandez M J
  95. Olid M
  96. Ortiz M
  97. Osorio J
  98. Pagan J
  99. Parra P
  100. Perez Ductor C
  101. Perez Pinar M
  102. Peris M L
  103. Pesce M L
  104. Porras J A
  105. Prieto Ganan L M
  106. Puche G
  107. Rivas A
  108. Rivera Civico F
  109. Rodriguez Cobo A
  110. Ruiz Artacho P
  111. Ruiz Gimenez N
  112. Ruiz Torregrosa P
  113. Salgueiro G
  114. Sendin V
  115. Sierra Palomares G
  116. Siguenza P
  117. Sole A
  118. Suarez Fernandez S
  119. Tascon Rodriguez R
  120. Tirado R
  121. Toda M R
  122. Tolosa C
  123. Torrecillas A
  124. Trujillo Santos J
  125. Tudela L
  126. Tung Chen Y
  127. Valle R
  128. Varona J F
  129. Vega Romero E
  130. Vidal G
  131. Villares P
  132. You J S
  133. Ay C
  134. Nopp S
  135. Pabinger I
  136. Erard M
  137. Van Thillo Q
  138. Carbonell S E
  139. Montenegro A C
  140. Roa J
  141. Grenar P
  142. Hirmerova J
  143. Accassat S
  144. Boulmerka I
  145. Bura Riviere A
  146. Catella J
  147. Chopard R
  148. Couturaud F
  149. Crichi B
  150. Demir A
  151. Espitia O
  152. Le Mao R
  153. Mahe I
  154. Morange P
  155. Moustafa F
  156. Plaisance L
  157. Poenou G
  158. Quere I
  159. Sarlon Bartoli G
  160. Suchon P
  161. Versini E
  162. Khodayari A
  163. Sadeghipour P
  164. Yadangi S
  165. Dally N
  166. Barillari G
  167. Basaglia M
  168. Bilora F
  169. Bissacco D
  170. Bortoluzzi C
  171. Bortoluzzi M
  172. Brandolin B
  173. Casana R
  174. Ciammaichella M M
  175. Colavolpe L
  176. Guida A
  177. Lambertenghi Deliliers D
  178. Mastroiacovo D
  179. Mazzarelli U
  180. Mumoli N
  181. Pizzuti V
  182. Poz A
  183. Scarinzi P
  184. Simeon V
  185. Siniscalchi C
  186. Visona A
  187. Vo Hong N
  188. Zalunardo B
  189. Cesnieks H
  190. Skride A
  191. Zicans M
  192. Flores Ramirez C
  193. Mendoza Romo Ramirez M
  194. Tarin Recendez D
  195. Fonseca S
  196. Fontes C
  197. Meireles J
  198. Kuzmanoski I
  199. Zdraveska M
  200. Ackermann D
  201. Barco S
  202. Sonderer M
  203. Angiolillo D J
  204. Ortega Paz L
  205. Tafur A J
  206. Nguyen S T
  207. Pham K Q
  208. Tran G B

Source: European Journal of Vascular and Endovascular Surgery Published:2026


Abstract

Objective: Post-thrombotic syndrome (PTS) is a frequent chronic complication of deep vein thrombosis (DVT), yet predictors of its individual manifestations remain poorly characterised. Methods: In a multicentre prospective cohort of 3 610 adults with a first symptomatic lower limb DVT enrolled in the RIETE registry, PTS manifestations were assessed at 12, 24, and 36 months. Villalta components were dichotomised to enhance reproducibility across centres. Multivariable logistic regression was used to identify independent baseline predictors and early post-diagnosis exposures associated with PTS symptoms, signs, and venous ulceration. Results: At 12 months, 34.7% of patients reported symptoms, 43.2% had signs, and 1.1% developed venous ulcers (increasing to 4.5% at 36 months). Female gender (adjusted odds ratio [aOR] 1.24, 95% confidence interval [CI] 1.07 – 1.44) and younger age (aOR 0.75, 95% CI 0.60 – 0.93 for ≥ 80 years vs. < 80 years) predicted symptoms but not signs or ulcers. Older age was associated with signs and ulcers. Higher body weight and proximal DVT predicted symptoms and signs, while ulcer risk increased in a dose dependent manner with body weight, particularly in men (aOR 4.12, 95% CI 1.18 – 14.3). Elastic stocking use was associated with symptom reporting at 12 months. Thrombolysis and shorter anticoagulation duration were associated with fewer PTS related signs. Associations remained generally consistent over time. Conclusion: Predictors differ across PTS domains, suggesting distinct pathophysiologic pathways and highlighting the need for risk stratified follow up and targeted prevention strategies after DVT. © 2026 European Society for Vascular Surgery. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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