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The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial Publisher Pubmed



Majidi N1 ; Rabbani F2 ; Gholami S3 ; Gholamalizadeh M4 ; Bourbour F5 ; Rastgoo S5 ; Hajipour A6 ; Shadnoosh M7 ; Akbari ME4 ; Bahar B8 ; Ashoori N5 ; Alizadeh A9 ; Samipoor F3 ; Moslem A10 Show All Authors
Authors
  1. Majidi N1
  2. Rabbani F2
  3. Gholami S3
  4. Gholamalizadeh M4
  5. Bourbour F5
  6. Rastgoo S5
  7. Hajipour A6
  8. Shadnoosh M7
  9. Akbari ME4
  10. Bahar B8
  11. Ashoori N5
  12. Alizadeh A9
  13. Samipoor F3
  14. Moslem A10
  15. Doaei S11
  16. Suzuki K12

Source: Frontiers in Immunology Published:2021


Abstract

Introduction: Vitamin C has been reported to have beneficial effects on patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of vitamin C supplementation on pathological parameters and survival duration of critically ill patients with COVID-19. Methods: This clinical trial was conducted on 120 hospitalized critically ill patients infected with COVID-19. The intervention group (n = 31) received one capsule of 500 mg of vitamin C daily for 14 days. The control group (n = 69) received the same nutrition except for vitamin C supplements. Measurement of pathological and biochemical parameters was performed at baseline and after 2 weeks of the intervention. Results: Following 2 weeks of vitamin C supplementation, the level of serum K was significantly lower in the patients compared with the control group (3.93 vs. 4.21 mEq/L, p < 0.01). Vitamin C supplementation resulted in a higher mean survival duration compared with that of the control group (8 vs. 4 days, p < 0.01). There was a linear association between the number of days of vitamin C intake and survival duration (B = 1.66, p < 0.001). The vitamin C supplementation had no effect on blood glucose, mean arterial pressure, arterial blood gas (ABG) parameters, Glasgow Coma Scale (GCS), kidney function, cell blood count (CBC), hemoglobin (Hb), platelet (Plt), partial thromboplastin time (PTT), albumin, hematocrit (Hct), and other serum electrolytes including sodium (Na), calcium, and phosphorus (P). Conclusion: The present study demonstrated the potential of vitamin C supplementation in enhancing the survival duration of critically ill patients with COVID-19. Clinical Trial Registration: https://www.irct.ir/trial/55074, identifier IRCT20151226025699N5. Copyright © 2021 Majidi, Rabbani, Gholami, Gholamalizadeh, BourBour, Rastgoo, Hajipour, Shadnoosh, Akbari, Bahar, Ashoori, Alizadeh, Samipoor, Moslem, Doaei and Suzuki.
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