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Increased Expression of the Receptor for Advanced Glycation End-Products (Rage) Is Associated With Advanced Breast Cancer Stage Publisher Pubmed



Nankali M1 ; Karimi J1 ; Goodarzi MT1 ; Saidijam M2 ; Khodadadi I1 ; Razavi ANE3 ; Rahimi F1
Authors

Source: Oncology Research and Treatment Published:2016


Abstract

Background: The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. Methods: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. Results: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). Conclusions: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression. © 2016 S. Karger GmbH, Freiburg. All rights reserved.
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