Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
A Review on Iron Chelators in Treatment of Iron Overload Syndromes



Mobarra N1 ; Shanaki M2 ; Ehteram H3 ; Nasiri H4 ; Sahmani M5 ; Saeidi M6 ; Goudarzi M7 ; Pourkarim H8 ; Azad M9
Authors

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2016

Abstract

Iron chelation therapy is used to reduce iron overload development due to its deposition in various organs such as liver and heart after regular transfusion. In this review, different iron chelators implicated in treatment of iron overload in various clinical conditions have been evaluated using more up-to-date studies focusing on these therapeutic agents. Deferoxamine, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. Each of these chelators has their own advantages and disadvantages, various target diseases, levels of deposited iron and clinical symptoms of the afflicted patients which may affect their selection as the best modality. Taken together, in many clinical disorders, choosing a standard chelator does not have an accurate index which requires further clarifications. The aim of this review is to introduce and compare the different iron chelators regarding their advantages and disadvantages, usage dose and specific applications. i¿½ 2016, Tehran University of Medical Sciences (TUMS). All rights reserved.
Related Docs
View other Related Docs
1. Effect of Combined Versus Monotherapy With Deferoxamine and Deferiprone in Iron Overloaded Thalassemia Patients: A Randomized Clinical Trial, International Journal of Pediatrics (2016)
2. Comparison of Iron Chelation Effects of Deferoxamine, Deferasirox, and Combination of Deferoxamine and Deferiprone on Liver and Cardiac T2* Mri in Thalassemia Maior, Caspian Journal of Internal Medicine (2017)
3. Apolipoproteins A1, B, and Other Prognostic Biochemical Cardiovascular Risk Factors in Patients With Beta-Thalassemia Major, Hematology (2016)
Experts (# of related papers)
View all Related Experts
Mostafa Sadeghi (1)
Negar Omidi (1)
Other Related Docs
4. Reproductive Health Issues in Female Patients With Beta-Thalassaemia Major: A Narrative Literature Review, Journal of Obstetrics and Gynaecology (2020)
5. The Association of Pro-Oxidant/Antioxidant Balance and Blood Parameters in Patients With Beta-Thalassemia Major: A Cross-Sectional Study, Blood Research (2023)
6. Preparation and Bioavailability Analysis of Ferrous Bis Alanine Chelate As a New Micronutrient for Treatment of Iron Deficiency Anemia, Advanced Pharmaceutical Bulletin (2016)
7. Iron Deficiency and Anemia in Cancer Patients: The Role of Iron Treatment in Anemic Cancer Patients, Nutrition and Cancer (2020)
8. Serum Ferritin Levels and Irregular Use of Iron Chelators Predict Liver Iron Load in Patients With Major Beta Thalassemia: A Cross-Sectional Study, Croatian Medical Journal (2019)
9. Comparison of the Effects of Deferasirox Film-Coated Tablets (Jadenu®) and Deferasirox Dispersible Tablets (Exjade®) in Patients With Beta Thalassemia Major: A Preliminary Report of the Effects on the Satisfaction, Convenience, Cardiac/Liver Mri T2*, Serum Ferritin Level, and Biochemical Profiles, Frontiers in Pharmacology (2024)
10. The Comparison of Efficacy of Original Brand Deferoxamine With Generic Iranian Made Deferoxamine in Urinary Iron Excretion in Patients With Thalassemia Major, Iranian Journal of Blood and Cancer (2018)
11. Two Trade Names of Deferasirox (Osveral® and Exjade®) in Reduction of Iron Overload Parameters in Major Betathalassemia Patients: A Randomized Open Labeled Clinical Trial, Caspian Journal of Internal Medicine (2022)
12. Evaluating the Safety and Efficacy of Silymarin in Β-Thalassemia Patients: A Review, Hemoglobin (2015)
13. Beta-Thalassemia Major and Myocardial Iron Overload: A Longitudinal Study With Magnetic Resonance Imaging, Cardiology Research and Practice (2024)
14. The Effectiveness of Anemia Treatment With Injectable Iron Within 48 to 72 Hours Before Coronary Artery Bypass Surgery on Cardiac Function and Postoperative Outcome: A Randomized Clinical Trial, Journal of Iranian Medical Council (2024)
15. Association Between Iron Deposition in Splenic,Hepatic and Myocardial Tissues Assessed by T2*Relaxometry Technique, Caspian Journal of Internal Medicine (2021)
16. Correlation Between Heart and Liver Iron Levels Measured by Mri T2* and Serum Ferritin in Patients With Β-Thalassemia Major, International Journal of Pediatrics (2016)
17. Hepatic Iron Overload and Fibrosis in Patients With Beta Thalassemia Major After Hematopoietic Stem Cell Transplantation: A Pilot Study, International Journal of Hematology-Oncology and Stem Cell Research (2015)
18. Biodistribution Evaluation of 166Ho–Dtpa–Spion in Normal Rats, Journal of Radioanalytical and Nuclear Chemistry (2016)
19. The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial, Complementary Therapies in Medicine (2019)
20. Iron; the Missing Link of Depression Prevention and Treatment: A Systematic Review and Meta-Analysis, Journal of Biostatistics and Epidemiology (2024)