Graphene Oxide Incorporated Polycaprolactone/Chitosan/Collagen Electrospun Scaffold: Enhanced Osteogenic Properties for Bone Tissue Engineering Publisher Pubmed



Aidun A^{1, 2} ; Safaei Firoozabady A³ ; Moharrami M^{2, 4} ; Ahmadi A⁵ ; Haghighipour N¹ ; Bonakdar S¹ ; Faghihi S⁶
Source: Artificial Organs Published:2019

Abstract

This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% of graphene oxide (GO). Using standard tests and MG-63 cells, the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated, respectively. A non-significant decrease in nanofibers diameter was noted in scaffolds with a higher ratio of GO. The hydrophilicity and bioactivity of the scaffold surface, as well as cell attachment and proliferation, increased in correspondence to an increase in GO. The higher ratio of GO also improved the osteogenesis activity. GO increased the degradation rate, but it was negligible and seemed not enough to endanger stability. Modifying the scaffolds with GO did not make a significant change to the antibacterial effect. © 2019 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.