Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Lipid Accumulation Product (Lap) Index for the Diagnosis of Nonalcoholic Fatty Liver Disease (Nafld): A Systematic Review and Meta-Analysis Publisher Pubmed



Ebrahimi M1 ; Seyedi SA1 ; Nabipoorashrafi SA1 ; Rabizadeh S1 ; Sarzaeim M2 ; Yadegar A1 ; Mohammadi F1 ; Bahri RA1 ; Pakravan P1 ; Shafiekhani P1 ; Nakhjavani M1 ; Esteghamati A1
Authors

Source: Lipids in Health and Disease Published:2023


Abstract

Background: Lipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analysis. Methods and results: PubMed, Scopus, and Web of Science online databases were searched for eligible studies that investigated the association of the LAP index and NAFLD. Sixteen observational studies with 96,101 participants, including four cohort studies, one case‒control study and 11 cross-sectional studies with baseline data, were entered into this analysis. Fourteen studies reported a significant association between the LAP index and NAFLD, and two reported that this relation was not significant; two different meta-analyses (1- mean difference (MD) and 2- bivariate diagnostic test accuracy [DTA]) were conducted using Stata version 14. The LAP index was compared in subjects with and without NAFLD, and the difference was significant with 34.90 units (CI 95: 30.59–39.31, P < 0.001) of the LAP index. The DTA meta-analysis was conducted and showed that the LAP index pooled sensitivity and specificity for screening of NAFLD were 94% (CI95: 72%–99%, I2 = 99%, P < 0.001) and 85% (CI95: 62%–96%, I2 = 99%, P < 0.001), respectively. Conclusion: The LAP Index is an inexpensive, sensitive, and specific method to evaluate NAFLD and may be valuable for NAFLD screening. © 2023, The Author(s).
Other Related Docs