Tehran University of Medical Sciences

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Application of Polyaniline–Multiwalled Carbon Nanotubes Composite Fiber for Determination of Benzaldehyde in Injectable Pharmaceutical Formulations by Solid-Phase Microextraction Gc–Fid Using Experimental Design Publisher



Masoumi V1 ; Mohammadi A1, 2 ; Khoshayand MR1, 3 ; Ansari M4
Authors

Source: Journal of Analytical Chemistry Published:2017


Abstract

A polyaniline–multiwalled carbon nanotubes composite fiber was electrodeposited onto a platinum wire using cyclic voltammetry. This fiber was used for headspace solid-phase microextraction combined with gas chromatography and flame ionization detector of trace levels of benzaldehyde in some injectable pharmaceutical formulations. Three solid-phase microextraction parameters including temperature, time and stirring rate were investigated simultaneously using a three-level-three-factor Box–Behnken as experimental design on the extraction capability. The as-made fiber has a lifetime of over 300 extractions without any obvious decline in extraction efficiency. At the optimum conditions (extraction temperature 60°C, extraction time 15 min, stirring rate 700 rpm), the method displays excellent linearity over the concentration range of 25–1000 ng/mL of benzaldehyde with RSD values ranging from 1.0 to 6.8%. The limits of quantitation and detection were 25 and 10 ng/mL, respectively. © 2017, Pleiades Publishing, Ltd.
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