Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel Etv6-Ret Translocation: Report of 10 Cases Publisher Pubmed



Skalova A1, 2 ; Vanecek T2 ; Martinek P2 ; Weinreb I4 ; Stevens TM5 ; Simpson RHW6 ; Hyrcza M7 ; Rupp NJ8 ; Baneckova M1, 2 ; Slouka D10 ; Svoboda T11 ; Metelkova A12 ; Etebarian A13 ; Pavelka J2, 14 Show All Authors
Authors
  1. Skalova A1, 2
  2. Vanecek T2
  3. Martinek P2
  4. Weinreb I4
  5. Stevens TM5
  6. Simpson RHW6
  7. Hyrcza M7
  8. Rupp NJ8
  9. Baneckova M1, 2
  10. Slouka D10
  11. Svoboda T11
  12. Metelkova A12
  13. Etebarian A13
  14. Pavelka J2, 14
  15. Potts SJ3
  16. Christiansen J3
  17. Steiner P1, 2
  18. Michal M1, 9

Source: American Journal of Surgical Pathology Published:2018


Abstract

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.