Genetic Vaccine for Cancer Publisher



Valilou SF¹ ; Keshavarzfathi M^{1, 2, 3}
Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2019

Abstract

Genetic-based cancer vaccines, including two major types—DNA vaccines and RNA vaccines—have become an attractive immunotherapeutic approach against cancer due to their various advantages such as simplicity, stability, and safety. The results obtained in clinical trials showed that such DNA and RNA vaccines are required to be ameliorated in antigen expression and delivery methods to make them sufficiently effective in the clinic and provide promising outcomes. Engineering vaccine for modifying antigen presentation and processing pathways is one of the most important aspects that can be managed easily. This chapter will directly focus on providing information for both the DNA and RNA vaccines, including related clinical trials, immune responses, efficacy and adverse events, and also pros and cons of the each of the vaccine types. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd. All rights reserved.