A Probiotic Supplement, Lactobacillus Rhamnosus Gg, and Kefir Separately Can Improve Mood and Exhibit Potential Anti-Depressant-Like Activities in Mice Publisher



Soltanmoradi H^{1, 2} ; Maniati MS^{1, 3} ; Davoodabadi A² ; Mosapour A⁴ ; Tehrani SS^{5, 6} ; Pazhoohan M^{1, 2} ; Daemi F⁷ ; Khaleghzadehahangar H^{7, 8}
Source: Acta Alimentaria Published:2021

Abstract

Depression is a common psychiatric disorder that can be continuous or recurrent. It has been previously reported that intestine probiotics play an essential role in the bidirectional communication of the intestine and brain. This study aims to investigate the antidepressant effects of kefir, a probiotic supplement, and Lactobacillus rhamnosus GG and their potentials in depression-like behaviour treatment in two-week and four-week treatments. In the present study, BALB/c mice were used for this purpose. The saline- and fluoxetine-treated groups were designed as negative and positive control groups, respectively. The forced swimming and tail suspension tests have been performed to assess the level of depression-like activity. We have observed that two-week treatment reduces the duration of depression-like activities, and four-week treatment enhances the antidepressant properties. Overall, our results suggest that kefir, L. rhamnosus GG, and the investigated probiotic supplement have antidepressant-like properties. © 2021 Akademiai Kiado.