Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy

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Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy Publisher

Jalilpiran Y^{1, 2} ; Tanideh N³ ; Rahmdel S⁴ ; Azarpira N⁵ ; Mokhtari M⁶ ; Mazloom Z¹

Source: Gastroenterology and Hepatology from Bed to Bench Published:2020

Abstract

Aim: This study aimed to compare the effects of synbiotic soymilk fortified with whey protein concentrate and zinc sulfate with lactulose on bile duct ligated-induced HE. Background: Hepatic encephalopathy (HE) is seriously associated with neuromuscular and cognitive alterations. Methods: Eighty-two Sprague Dawley rats were randomly assigned into seven groups (sham, bile duct ligation (BDL), BDL + lactulose, BDL + soymilk (SM), BDL + Synbiotic soymilk (SSM), BDL + SSM + whey protein concentrate (WPC), BDL + SSM + WPC + ZnSO4). Different SM products, lactulose, and normal saline were administered via oral gavage (2 mL/rat/day). The serum and liver markers as well as liver histopathology were assessed after 28 days. Results: The SM products significantly reduced the serum alanine aminotransferase, albumin, and ammonia (P < 0.05). The levels of aspartate aminotransferase, endotoxin, and liver interleukin-6 improved significantly in all treatments, except for those receiving SM. SSM and SSM + WPC + ZnSO4 were the only effective products in reducing serum alkaline phosphatase (P < 0.05). Furthermore, the liver total antioxidant capacity was greater (P<0.05) in the SSM + WPC and SSM + WPC + ZnSO4 groups. The histopathological examinations confirmed the efficiency of all SM products in reducing liver fibrosis. Liver bile duct proliferation diminished only in the SSM + WPC and SSM + WPC+ ZnSO4 groups (P<0.05). Conclusion: This study showed the positive effects of different SM products, especially SSM + WPC and SSM + WPC + ZnSO4, on HE. Further studies are required to confirm our findings. © 2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.

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Style	Citing Format
MLA	Jalilpiran Y, et al.. "Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy." Gastroenterology and Hepatology from Bed to Bench, vol. 13, no. 1, 2020, pp. 64-76.
APA	Jalilpiran Y, Tanideh N, Rahmdel S, Azarpira N, Mokhtari M, Mazloom Z (2020). Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy. Gastroenterology and Hepatology from Bed to Bench, 13(1), 64-76.
Chicago	Jalilpiran Y, Tanideh N, Rahmdel S, Azarpira N, Mokhtari M, Mazloom Z. "Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy." Gastroenterology and Hepatology from Bed to Bench 13, no. 1 (2020): 64-76.
Harvard	Jalilpiran Y et al. (2020) 'Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy', Gastroenterology and Hepatology from Bed to Bench, 13(1), pp. 64-76.
Vancouver	Jalilpiran Y, Tanideh N, Rahmdel S, Azarpira N, Mokhtari M, Mazloom Z. Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy. Gastroenterology and Hepatology from Bed to Bench. 2020;13(1):64-76.
BibTex	@article{ author = {Jalilpiran Y and Tanideh N and Rahmdel S and Azarpira N and Mokhtari M and Mazloom Z}, title = {Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy}, journal = {Gastroenterology and Hepatology from Bed to Bench}, volume = {13}, number = {1}, pages = {64-76}, year = {2020} }
RIS	TY - JOUR AU - Jalilpiran Y AU - Tanideh N AU - Rahmdel S AU - Azarpira N AU - Mokhtari M AU - Mazloom Z TI - Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy JO - Gastroenterology and Hepatology from Bed to Bench VL - 13 IS - 1 SP - 64 EP - 76 PY - 2020 ER -

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