Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Dermatologic Presentations of Hyper Ige Syndrome in Pediatric Patients Publisher



Mahjoubi M1, 2 ; Rashedi R1 ; Samieefar N1, 3 ; Abdollahimajd F1, 4, 5 ; Rezaei N1, 6, 7
Authors

Source: Allergy, Asthma and Clinical Immunology Published:2025


Abstract

Background: Hyper-IgE Syndrome, also known as Job’s syndrome, is a rare primary immunodeficiency disorder characterized by recurrent infections and elevated levels of immunoglobulin E. While respiratory and systemic manifestations have been more emphasized, dermatological manifestations in Hyper-IgE Syndrome also play a significant role in disease presentation. Methods: This narrative review explores the dermatologic presentations of Hyper-IgE Syndrome in pediatric populations, including descriptions, associated symptoms/findings, and available treatment options. Results and conclusion: Neonatal rash, mucocutaneous candidiasis, noma neonatorum, psoriasis, cold staphylococcal abscesses, and candida onychomycosis are among the dermatological manifestations of Hyper-IgE Syndrome. Each manifestation has unique characteristics and treatment considerations, necessitating accurate recognition and diagnosis for effective management. Optimal treatment strategies involve a combination of supportive care, topical/systemic therapies, antifungal medications, and surgical interventions when necessary. Further research is needed to enhance our understanding of these manifestations and evaluate treatment modalities for individuals affected by Hyper-IgE Syndrome. © The Author(s) 2025.
Other Related Docs
6. The Diagnosis of Hyper Immunoglobulin E Syndrome Based on Project Management, Iranian Journal of Allergy# Asthma and Immunology (2015)
7. A Rare Case of Hyper Ige Syndrome With Vocal Cords Involvement, Iranian Journal of Allergy# Asthma and Immunology (2019)
11. Pulmonary Manifestations of Other Well-Defined Immunodeficiencies, Pulmonary Manifestations of Primary Immunodeficiency Diseases (2018)
13. Inborn Errors of Immunity and Cancers, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
15. Primary Immunodeficiencies and Cancers, Cancer Immunology: A Translational Medicine Context (2015)