Overview and Research Trends on Cluster Headache Disease: A Bibliometric and Natural Language Processing Approach Publisher



Hoseinnezhad M ; Khazaneha M ; Arvan H ; Togha M
Source: Acta Neurologica Scandinavica Published:2026

Abstract

Background: This study presents a comprehensive analysis of the trends and challenges in cluster headache research from 1936 to 2022, highlighting the increasing study trend and the significant contributions from the United States, Italy, and England. The study identifies the most important journals, productive authors, and centers in the field, shedding light on the defects and challenges in pathophysiology, genetics, diagnosis, treatment, and study methods of cluster headaches. Methods: Utilizing a bibliometric approach, the study examines the thematic and conceptual structural map, identifying key areas of focus in the pathophysiology, genetics, and neuroimaging studies of cluster headaches. The study also delves into the treatment phases and guidelines for cluster headaches, emphasizing the need for evidence-based and physiopathology-based treatment approaches. Results: The findings highlight the genetic and neuroimaging research gaps, the role of the hypothalamus, and the morphological alterations in the brain associated with cluster headaches. The study also discusses the limitations and challenges in the research and treatment of cluster headaches, emphasizing the need for improved clinical trial methodologies and treatment efficacy. Conclusion: The study concludes by underscoring the critical need for further research to address the limitations and challenges in understanding the pathophysiology, improving treatment efficacy, and enhancing the quality of life for individuals with cluster headaches. The study recommends future research with a comprehensive perspective to address the complexities and insufficiencies in the current understanding and treatment of cluster headaches. Copyright © 2026 Mohsen Hoseinnezhad et al. Acta Neurologica Scandinavica published by John Wiley & Sons Ltd.