Evaluation of Contrast Agent Dose and Diffusion Coefficient Measurement on Vessel Size Index Estimation Publisher Pubmed



Vejdani Afkham B¹ ; Masjoodi S¹ ; Oghabian MA¹ ; Ghodsi SR² ; Nazem Zadeh MR³ ; Esmati E⁴ ; Farzin M⁵ ; Gilasi M⁶ ; Hashemi H^{7, 8}
Source: Magnetic Resonance Materials in Physics# Biology and Medicine Published:2019

Abstract

Objectives: The goal of this study is to examine the effect of contrast agent (CA) dose and diffusion coefficient on the estimation of vessel size index (VSI). Materials and methods: Three groups of four participants were enrolled in this study and two different experiments were performed. Different dose of CA, namely 0.1 mmol/kg and 0.05 mmol/kg were assessed in two groups of normal subjects. Diffusion coefficient effect was assessed in the third group with high-grade glioma. Imaging included gradient echo and spin-echo DSC and DTI on a 3-T MR Scanner. Results: VSI estimation using half of standard dose of CA showed higher values compared to the application of standard, with a ratio of 2 for the WM and 1.5 for the GM. VSI estimates for tumor tissues (22 µm) were considerably higher compared to contra-lateral Normal-Appearing WM (NAWM, 4 µm, P < 0.01) and Normal-Appearing GM (NAGM, 8 µm, P < 0.04). Discussion: Application of standard dose for CA injection and also taking into account the effect of diffusion coefficient can lead to a better correlation of VSI with previous theoretically predicted values and improvement of individual diagnostics in tumor evaluations. © 2019, European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).