Hbv Reactivation in Rheumatic Diseases Patients Under Therapy: A Meta-Analysis Publisher Pubmed



Moghoofei M¹ ; Mostafaei S² ; Ashrafganjouei A² ; Kavosi H² ; Mahmoudi M²
Source: Microbial Pathogenesis Published:2018

Abstract

Background Hepatitis B is one of the most common infectious diseases worldwide. In patients undergoing immunosuppressive therapy such as rheumatic diseases, reactivation of hepatitis B virus (HBV) is considered clinically important. This systematic review and meta-analysis were performed to determine the prevalence rate of HBV reactivation in rheumatic patients from different parts of the world. Methods The authors performed a systematic literature review from several reliable databases including Scopus, ISI Web of Science and PubMed. Furthermore, the keywords of this research were “Hepatitis B virus” “Rheumatic diseases” “HBV reactivation” “Anti-TNF” “DMARDs” and “Biologic agents”. Results The authors selected 30 studies out of 983 for the present review. The overall estimation of the prevalence of HBV reactivation was 1.4 (95% confidence interval (CI): 1.3–1.6). Also, the heterogeneity in estimating the pooled prevalence among the studies was shown; Cochran Q test, P < 0.001, I2 = 99.9%. It should be noted that max and min reactivation rate of HBV were in Italy and France respectively. Conclusions Rheumatic disease patients with resolved hepatitis B should be tightly monitored for possible HBV reactivation by elevation of liver enzymes and HBV DNA levels. © 2017 Elsevier Ltd