The Impact of Epithelial-Mesenchymal Transition (Emt) Induced by Metabolic Processes and Intracellular Signaling Pathways on Chemo-Resistance, Metastasis, and Recurrence in Solid Tumors Publisher Pubmed



Liaghat M^{1, 2} ; Ferdousmakan S³ ; Mortazavi SH⁴ ; Yahyazadeh S⁵ ; Irani A⁶ ; Banihashemi S⁷ ; Seyedi Asl FS⁸ ; Akbari A^{2, 9} ; Farzam F¹⁰ ; Aziziyan F^{2, 10} ; Bakhtiyari M^{2, 11} ; Arghavani MJ¹² ; Zalpoor H^{2, 9} ; Nabiafjadi M¹⁰
Source: Cell Communication and Signaling Published:2024

Abstract

The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a better understanding of the intricate processes underlying EMT and its role in tumor growth may lead to the development of novel therapeutic approaches for the treatment of solid tumors. This review article focuses on the signals that promote EMT and metabolism, the intracellular signaling pathways leading to EMT, and the network of interactions between EMT and cancer cell metabolism. Furthermore, the functions of EMT in treatment resistance, recurrence, and metastasis of solid cancers are covered. Lastly, treatment approaches that focus on intracellular signaling networks and metabolic alterations brought on by EMT will be discussed. © The Author(s) 2024.