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Nanoarchitectonics of Doxycycline-Loaded Vitamin E-D-Α-Tocopheryl Polyethylene Glycol 1000 Succinate Micelles for Ovarian Cancer Stem Cell Treatment Publisher Pubmed



Hajikhani Z1 ; Haririan I1, 2, 3 ; Akrami M1, 2 ; Hajikhani S4
Authors

Source: Nanomedicine Published:2023


Abstract

Aim: This study aim to develop doxycycline within the D-α-tocopheryl polyethylene glycol 1000 succinate micelle platform as an anticancer stem cell agent. Materials & methods: The optimized nanomicelle formulation was prepared using the solvent casting method and evaluated through physicochemical and biological characterization. Results: Nanomicelles exhibited mean particle sizes of 14.48 nm (polydispersity index: 0.22) using dynamic light scattering and 18.22 nm using transmission electron micrography. Drug loading and encapsulation efficiency were 2% and 66.73%, respectively. Doxycycline-loaded micelles exhibited sustained release, with 98.5% released in 24 h. IC50 values were 20 μg/ml for free drug and 5 μg/ml for micelles after 48 h of cell exposure. A significant 74% reduction in CD44 biomarker and 100% colony formation inhibition were observed. Conclusion: Doxycycline in hemo/biocompatible nanomicelles holds potential for ovarian cancer stem cell therapy. © 2023 Future Medicine Ltd.
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