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Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles Publisher Pubmed

Summary: Can click chemistry create new drugs? A study shows intramolecular click reactions produce 1,2,3-triazoles, advancing molecule synthesis for medicines. #DrugSynthesis #Chemistry

Tashrifi Z1 ; Mohammadi Khanaposhtani M2 ; Bahadorikhalili S3 ; Larijani B1 ; Mahdavi M1
Authors

Source: Current Organic Synthesis Published:2024


Abstract

Click Chemistry, as a powerful tool, has been used for the synthesis of a variety of 1,2,3-triazoles. Among click cycloaddition reactions, intramolecular click reactions carried out in azido-alkyne precursors has not been thoroughly reviewed. Hence, in this review, we have sum-marized and categorised the recent literature (from 2012 on) based on the azidoalkynyl precursor's type and a brief and concise description of the involved mechanisms is presented. Accordingly, we have classified the relevant literature into three categories: (1) substitution precursors (2) addition and (3) multi-component reaction (MCR) products. © 2024 Bentham Science Publishers.
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