Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Vitamin D Deficiency Associated With Differentiated Thyroid Carcinoma: A Case- Control Study Publisher Pubmed



Heidari Z1 ; Nikbakht M1 ; Mashhadi MA2 ; Jahantigh M3 ; Mansournia N4 ; Sheikhi V5 ; Mansournia MA6
Authors

Source: Asian Pacific Journal of Cancer Prevention Published:2017


Abstract

Objective: In recent decades, the incidence of thyroid cancer has increased throughout the world. It is unclear whether factors such as vitamin D deficiency may have been involved in this increase. The present case-control study was conducted to examine any association between Vitamin D deficiency and thyroid cancers. Methods: The study was conducted on 85 patients with differentiated thyroid cancer diagnosed based on fine needle aspiration biopsy as the case group and 85 healthy controls. Serum levels of vitamin D were evaluated before thyroidectomy. For each patient in the case group, one healthy euthyroid person without any thyroid nodules from the general population matched based on season, sex, age (± 1 year) and BMI (± 1) was selected. Finally, 85 pairs were obtained considering inclusion and exclusion criteria. Thyroid function, thyroid antibodies and serum vitamin D were assessed and thyroid sonography was performed in all participants. Results: In the patient group, 72 (85%) were female and 13 (15%) were male. The mean (SD) serum vitamin D level was 8.00 (±3.7) in patient group, as compared to 13.4 (±7.90) in the control group, the difference being significant (OR: 6, 95 % CI: 1.02-113.3; P=0.046). Conclusion: A significant association was noted between vitamin D deficiency and differentiated thyroid cancer. Further studies with a prospective design are necessary to further define the roles of this factor.
Other Related Docs
7. Evaluation of Serum Vitamin B12 Levels in Patients With Colon and Breast Cancer: A Case-Control Study, International Journal of Hematology-Oncology and Stem Cell Research (2023)
13. Causal Methods for Observational Research: A Primer, Archives of Iranian Medicine (2018)