Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry

Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry Publisher Pubmed

Souissi A ; Patti F ; Spelman T ; Chisari C ; Gargouri A ; John N ; Kermode AG ; Kalincik T ; Butzkueven H ; Sajedi SA ; Lechnerscott J ; Roos I ; Laureys G ; Taylor B Show All Authors

Souissi A
Patti F
Spelman T
Chisari C
Gargouri A
John N
Kermode AG
Kalincik T
Butzkueven H
Sajedi SA
Lechnerscott J
Roos I
Laureys G
Taylor B
Alroughani R
Khoury SJ
Macdonell R
Weinstockguttman B
Havrdova EK
Maimone D
Reddel S
Fabispedrini M
Willekens B
Moghadasi AN
Lalive P
Lugaresi A
Ozakbas S
Solaro C
Cardenasrobledo S
Shaygannejad V
Etemadifar M
Boz C
Eichau S
Tomassini V
Terzi M
Prat A
Habek M
Blanco Y
Altintas A
Gerlach O
Turkoglu R
Buzzard K
Skibina O
Soysal A
Van Der Walt A
Hughes S
Van Pesch V
Foschi M
Surcinelli A
Prevost J
Ramotello C
Mcguigan C
Sa MJ
Kuhle J
Spitaleri D
Singhal B
Ampapa R
De Gans K
Petersen T
Simu M
Lapointe E
Sanchezmenoyo JL
Gray O
Garber J
Agueramorales E
Grosspaju K
Castillotrivino T
Alasmi A
Grigoriadis N
Inshasi J
Alharbi T
Hardy TA
Ramanathan S
Cambron M
Shuey N
Sempere AP
Csepany T
Trevinofrenk I
Rozsa C
Cauchi M
Karabudak R
Mrabet S
Gouider R

Source: Journal of Neurology Published:2026

Abstract

Background: Multiple Sclerosis (MS) severity is influenced by several factors. Understanding the impact of age at disease onset may help to better characterize clinical and disease features across age groups. This study aimed to characterize the clinical features and disability outcomes of late-onset MS (LOMS) and very late-onset MS (vLOMS), compared to adult-onset MS (AOMS). Methods: We conducted an observational study using data from the MSBase registry and categorized patients based on age at MS onset: AOMS (18–39 years), transition onset (40–49 years), LOMS (50–59 years), and vLOMS (≥ 60 years). Disease progression was assessed using the 24 week confirmed disability progression, EDSS4 and 6 milestones, conversion to secondary progressive MS(SPMS), and the first progression independent of relapse activity (PIRA) event. Cox proportional hazard regression models were used to determine unadjusted hazard ratios(HR), and propensity score inverse probability of treatment weighting(PS-IPTW) balanced covariate distributions. Results: Among 81,236 patients, 5.2% had LOMS and 1% had vLOMS. Primary progressive MS was more frequent in LOMS and vLOMS (21.7 and 24%, respectively). Patients with LOMS and vLOMS had a significantly increased risk of 24 week confirmed disability progression (HR:LOMS = 1.39, vLOMS = 1.80), EDSS 4 (HR:LOMS = 2.14, vLOMS = 2.95), EDSS 6 (HR:LOMS = 2.33, vLOMS = 6.33), SPMS (HR:LOMS = 1.62, vLOMS = 2.38), and first PIRA event (HR:LOMS = 2.12, vLOMS = 2.93). Conclusion: LOMS and vLOMS exhibited a more progressive disease onset and higher disability milestones compared with AOMS. © Springer-Verlag GmbH Germany, part of Springer Nature 2026.

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Style	Citing Format
MLA	Souissi A, et al.. "Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry." Journal of Neurology, vol. 273, no. 2, 2026, pp. -.
APA	Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, Kermode AG, Kalincik T, Butzkueven H, Sajedi SA, Lechnerscott J, Roos I, Laureys G, Taylor B, Alroughani R, Khoury SJ, Macdonell R, Weinstockguttman B, Havrdova EK, ... Gouider R (2026). Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry. Journal of Neurology, 273(2), -.
Chicago	Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, Kermode AG, et al.. "Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry." Journal of Neurology 273, no. 2 (2026): -.
Harvard	Souissi A et al. (2026) 'Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry', Journal of Neurology, 273(2), pp. -.
Vancouver	Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, et al.. Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry. Journal of Neurology. 2026;273(2):-.
BibTex	@article{ author = {Souissi A and Patti F and Spelman T and Chisari C and Gargouri A and John N and Kermode AG and Kalincik T and Butzkueven H and Sajedi SA and Lechnerscott J and Roos I and Laureys G and Taylor B and Alroughani R and Khoury SJ and Macdonell R and Weinstockguttman B and Havrdova EK and Maimone D and Reddel S and Fabispedrini M and Willekens B and Moghadasi AN and Lalive P and Lugaresi A and Ozakbas S and Solaro C and Cardenasrobledo S and Shaygannejad V and Etemadifar M and Boz C and Eichau S and Tomassini V and Terzi M and Prat A and Habek M and Blanco Y and Altintas A and Gerlach O and Turkoglu R and Buzzard K and Skibina O and Soysal A and Van Der Walt A and Hughes S and Van Pesch V and Foschi M and Surcinelli A and Prevost J and Ramotello C and Mcguigan C and Sa MJ and Kuhle J and Spitaleri D and Singhal B and Ampapa R and De Gans K and Petersen T and Simu M and Lapointe E and Sanchezmenoyo JL and Gray O and Garber J and Agueramorales E and Grosspaju K and Castillotrivino T and Alasmi A and Grigoriadis N and Inshasi J and Alharbi T and Hardy TA and Ramanathan S and Cambron M and Shuey N and Sempere AP and Csepany T and Trevinofrenk I and Rozsa C and Cauchi M and Karabudak R and Mrabet S and Gouider R}, title = {Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry}, journal = {Journal of Neurology}, volume = {273}, number = {2}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Souissi A AU - Patti F AU - Spelman T AU - Chisari C AU - Gargouri A AU - John N AU - Kermode AG AU - Kalincik T AU - Butzkueven H AU - Sajedi SA AU - Lechnerscott J AU - Roos I AU - Laureys G AU - Taylor B AU - Alroughani R AU - Khoury SJ AU - Macdonell R AU - Weinstockguttman B AU - Havrdova EK AU - Maimone D AU - Reddel S AU - Fabispedrini M AU - Willekens B AU - Moghadasi AN AU - Lalive P AU - Lugaresi A AU - Ozakbas S AU - Solaro C AU - Cardenasrobledo S AU - Shaygannejad V AU - Etemadifar M AU - Boz C AU - Eichau S AU - Tomassini V AU - Terzi M AU - Prat A AU - Habek M AU - Blanco Y AU - Altintas A AU - Gerlach O AU - Turkoglu R AU - Buzzard K AU - Skibina O AU - Soysal A AU - Van Der Walt A AU - Hughes S AU - Van Pesch V AU - Foschi M AU - Surcinelli A AU - Prevost J AU - Ramotello C AU - Mcguigan C AU - Sa MJ AU - Kuhle J AU - Spitaleri D AU - Singhal B AU - Ampapa R AU - De Gans K AU - Petersen T AU - Simu M AU - Lapointe E AU - Sanchezmenoyo JL AU - Gray O AU - Garber J AU - Agueramorales E AU - Grosspaju K AU - Castillotrivino T AU - Alasmi A AU - Grigoriadis N AU - Inshasi J AU - Alharbi T AU - Hardy TA AU - Ramanathan S AU - Cambron M AU - Shuey N AU - Sempere AP AU - Csepany T AU - Trevinofrenk I AU - Rozsa C AU - Cauchi M AU - Karabudak R AU - Mrabet S AU - Gouider R TI - Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry JO - Journal of Neurology VL - 273 IS - 2 SP - EP - PY - 2026 ER -

Style

Citing Format

MLA

Souissi A, et al.. "Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry." Journal of Neurology, vol. 273, no. 2, 2026, pp. -.

APA

Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, Kermode AG, Kalincik T, Butzkueven H, Sajedi SA, Lechnerscott J, Roos I, Laureys G, Taylor B, Alroughani R, Khoury SJ, Macdonell R, Weinstockguttman B, Havrdova EK, ... Gouider R (2026). Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry. Journal of Neurology, 273(2), -.

Chicago

Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, Kermode AG, et al.. "Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry." Journal of Neurology 273, no. 2 (2026): -.

Harvard

Souissi A et al. (2026) 'Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry', Journal of Neurology, 273(2), pp. -.

Vancouver

Souissi A, Patti F, Spelman T, Chisari C, Gargouri A, John N, et al.. Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry. Journal of Neurology. 2026;273(2):-.

BibTex

@article{ author = {Souissi A and Patti F and Spelman T and Chisari C and Gargouri A and John N and Kermode AG and Kalincik T and Butzkueven H and Sajedi SA and Lechnerscott J and Roos I and Laureys G and Taylor B and Alroughani R and Khoury SJ and Macdonell R and Weinstockguttman B and Havrdova EK and Maimone D and Reddel S and Fabispedrini M and Willekens B and Moghadasi AN and Lalive P and Lugaresi A and Ozakbas S and Solaro C and Cardenasrobledo S and Shaygannejad V and Etemadifar M and Boz C and Eichau S and Tomassini V and Terzi M and Prat A and Habek M and Blanco Y and Altintas A and Gerlach O and Turkoglu R and Buzzard K and Skibina O and Soysal A and Van Der Walt A and Hughes S and Van Pesch V and Foschi M and Surcinelli A and Prevost J and Ramotello C and Mcguigan C and Sa MJ and Kuhle J and Spitaleri D and Singhal B and Ampapa R and De Gans K and Petersen T and Simu M and Lapointe E and Sanchezmenoyo JL and Gray O and Garber J and Agueramorales E and Grosspaju K and Castillotrivino T and Alasmi A and Grigoriadis N and Inshasi J and Alharbi T and Hardy TA and Ramanathan S and Cambron M and Shuey N and Sempere AP and Csepany T and Trevinofrenk I and Rozsa C and Cauchi M and Karabudak R and Mrabet S and Gouider R}, title = {Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry}, journal = {Journal of Neurology}, volume = {273}, number = {2}, pages = {-}, year = {2026} }

RIS

TY - JOUR
AU - Souissi A
AU - Patti F
AU - Spelman T
AU - Chisari C
AU - Gargouri A
AU - John N
AU - Kermode AG
AU - Kalincik T
AU - Butzkueven H
AU - Sajedi SA
AU - Lechnerscott J
AU - Roos I
AU - Laureys G
AU - Taylor B
AU - Alroughani R
AU - Khoury SJ
AU - Macdonell R
AU - Weinstockguttman B
AU - Havrdova EK
AU - Maimone D
AU - Reddel S
AU - Fabispedrini M
AU - Willekens B
AU - Moghadasi AN
AU - Lalive P
AU - Lugaresi A
AU - Ozakbas S
AU - Solaro C
AU - Cardenasrobledo S
AU - Shaygannejad V
AU - Etemadifar M
AU - Boz C
AU - Eichau S
AU - Tomassini V
AU - Terzi M
AU - Prat A
AU - Habek M
AU - Blanco Y
AU - Altintas A
AU - Gerlach O
AU - Turkoglu R
AU - Buzzard K
AU - Skibina O
AU - Soysal A
AU - Van Der Walt A
AU - Hughes S
AU - Van Pesch V
AU - Foschi M
AU - Surcinelli A
AU - Prevost J
AU - Ramotello C
AU - Mcguigan C
AU - Sa MJ
AU - Kuhle J
AU - Spitaleri D
AU - Singhal B
AU - Ampapa R
AU - De Gans K
AU - Petersen T
AU - Simu M
AU - Lapointe E
AU - Sanchezmenoyo JL
AU - Gray O
AU - Garber J
AU - Agueramorales E
AU - Grosspaju K
AU - Castillotrivino T
AU - Alasmi A
AU - Grigoriadis N
AU - Inshasi J
AU - Alharbi T
AU - Hardy TA
AU - Ramanathan S
AU - Cambron M
AU - Shuey N
AU - Sempere AP
AU - Csepany T
AU - Trevinofrenk I
AU - Rozsa C
AU - Cauchi M
AU - Karabudak R
AU - Mrabet S
AU - Gouider R
TI - Effect of Late-Onset on Multiple Sclerosis Phenotype and Outcome: Evidence From a Multi-National Registry
JO - Journal of Neurology
VL - 273
IS - 2
SP -
EP -
PY - 2026
ER -

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