A Nanocomposite Prepared From Reduced Graphene Oxide, Gold Nanoparticles and Poly(2-Amino-5-Mercapto-1,3,4-Thiadiazole) for Use in an Electrochemical Sensor for Doxorubicin Publisher Pubmed



Ghanbari MH^{1, 2, 3} ; Shahdostfard F^{4, 5} ; Salehzadeh H³ ; Ganjali MR^{6, 7} ; Iman M^{1, 2} ; Rahiminasrabadi M^{1, 2} ; Ahmadi F^{8, 9}
Source: Microchimica Acta Published:2019

Abstract

A nanocomposite was prepared with reduced graphene oxide, gold nanoparticles and an electropolymerized film made from 2-amino-5-mercapto-1,3,4-thiadiazole. An electrochemical sensor for doxorubicin (DOX) was constructed by modifying a glassy carbon electrode (GCE) with the nanocomposite. The modified GCE was studied by electrochemical techniques which showed it to enable highly sensitive sensing of DOX. Response (typically measured at a typical working potential of −0.56 V vs. Ag/AgCl) is linear in the 30 pM to 30 nM and 30 nM to 30 μM DOX concentration ranges, with a limit of detection (LOD) of 9 pM (at an S/N ratio of 3). The method was applied to the determination of DOX in serum and gave recoveries that ranged between 92 and 108%. [Figure not available: see fulltext.]. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.