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The Effect of Resveratrol Supplementation on C-Reactive Protein (Crp) in Type 2 Diabetic Patients: Results From a Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Hosseini H1 ; Koushki M1 ; Khodabandehloo H2 ; Fathi M2 ; Panahi G1 ; Teimouri M1 ; Majidi Z1 ; Meshkani R1
Authors

Source: Complementary Therapies in Medicine Published:2020


Abstract

Objective: C-reactive protein (CRP) is considered to be an inflammatory marker in type 2 diabetes (T2D) and it is produced by liver cells. The evidence has suggested that resveratrol has anti-inflammatory effect. This study aimed to evaluate the effect of resveratrol supplementation on CRP level in patients with T2D using a systematic review and meta-analysis of randomized controlled trials. Methods: Electronic databases were completely searched using Medline, ISI Web of Science, EMBASE and Cochrane Library and Scopus until October 2019. Meta-analysis was performed using random-effects model and inverse variance method. Heterogeneity and publication bias were evaluated in selected studies. Sensitivity analyses and prespecified subgroup were conducted to evaluate potential heterogeneity. Meta-regression was performed to assess the effect of potential confounders on the estimated effect sizes. Results: Six trials comprising a total of 491 subjects were included in this meta-analysis. The results showed significant reduction in the level of CRP [SMD (-0.34 mg/l) (95 % CI, -0.52, to -0.16) p < 0.05] in participants with T2D following supplementation with resveratrol. No significant publication bias was observed in the meta-analysis. Subgroup and sensitivity analyses indicated that the pooled effects of resveratrol supplementation on CRP level in T2D patients were affected by resveratrol dose and duration of resveratrol. Random-effects meta-regression did not indicate any significant association of CRP level with potential confounders including resveratrol dose, duration of treatment, age and gender of type 2 diabetic patients. Conclusion: We found a significant reduction in CRP level in patients with type 2 diabetes, who received resveratrol supplementation. © 2019 Elsevier Ltd
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