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Low Level of Adiponectin Predicts the Development of Nonalcoholic Fatty Liver Disease: Is It Irrespective to Visceral Adiposity Index, Visceral Adipose Tissue Thickness and Other Obesity Indices? Publisher Pubmed



Ebrahimi R1 ; Shanaki M2 ; Mohassel Azadi S1 ; Bahiraee A3 ; Radmard AR4 ; Poustchi H5 ; Emamgholipour S1
Authors

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

We aimed to study the correlation of adiponectin level with insulin resistance (IR), carotid intima-media thickness (cIMT), and various obesity indices especially visceral adipose tissue (VAT) thickness, and visceral adiposity index (VAI), in patients with NAFLD (n = 41), T2D (n = 22), NAFLD + T2D (n = 41), and healthy subjects (n = 20). Results showed the median level of adiponectin in patients with NAFLD (2.97 μg/mL) and ones with NAFLD + T2D (3.21 μg/mL) is significantly lower rather than in controls (4.39 μg/mL). Moreover, VAI is the only predictor for adiponectin concentration in the combination of patient groups and also in all participants independent of IR and other obesity indices. Adiponectin level had also a positive correlation with cIMT and IR in NAFLD patients. Interestingly, lower level of adiponectin was associated with the presence of T2D, NAFLD, and NAFLD + T2D independent of IR and obesity indices. Collectively, it seems that VAI reflecting visceral adipose tissue function is a possible predictor of adiponectin level. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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