Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Targeting Stats in Neuroinflammation: The Road Less Traveled! Publisher Pubmed



Nabavi SM1 ; Ahmed T2 ; Nawaz M2 ; Devi KP3 ; Balan DJ3 ; Pittala V4 ; Arguellescastilla S5 ; Testai L6 ; Khan H7 ; Sureda A8 ; De Oliveira MR9 ; Vacca RA10 ; Xu S11 ; Yousefi B12, 13 Show All Authors
Authors
  1. Nabavi SM1
  2. Ahmed T2
  3. Nawaz M2
  4. Devi KP3
  5. Balan DJ3
  6. Pittala V4
  7. Arguellescastilla S5
  8. Testai L6
  9. Khan H7
  10. Sureda A8
  11. De Oliveira MR9
  12. Vacca RA10
  13. Xu S11
  14. Yousefi B12, 13
  15. Curti V14
  16. Daglia M14
  17. Sobarzosanchez E15, 16
  18. Filosa R17
  19. Nabavi SF1, 18
  20. Majidinia M19
  21. Dehpour AR20, 21
  22. Shirooie S22

Source: Pharmacological Research Published:2019


Abstract

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. The ability to diminish the STAT-induced transcription of inflammatory genes is documented for both natural compounds (such as polyphenols) and chemical drugs. Among polyphenols, quercetin and curcumin directly inhibit STAT, while Berberis vulgaris L. and Sophora alopecuroides L extracts act indirectly. Also, the Food and Drug Administration has approved several JAK/STAT inhibitors (direct or indirect) for treating inflammatory diseases, indicating STAT can be considered as a therapeutic target for neuroinflammatory pathologies. Considering the encouraging data obtained so far, clinical trials are warranted to demonstrate the effectiveness and potential use in the clinical practice of STAT inhibitors to treat inflammation-associated neurodegenerative pathologies. © 2018 Elsevier Ltd
Other Related Docs
4. Neurotransmission Systems in Parkinson's Disease, Reviews in the Neurosciences (2017)
13. Jak Inhibitors in the Treatment of Lichen Planopilaris, Skin Appendage Disorders (2024)
19. Implications on the Therapeutic Potential of Statins Via Modulation of Autophagy, Oxidative Medicine and Cellular Longevity (2021)