Functionalization of Zno Nanoparticles by 3-Mercaptopropionic Acid for Aqueous Curcumin Delivery: Synthesis, Characterization, and Anticancer Assessment Publisher Pubmed



Ghaffari SB¹ ; Sarrafzadeh MH¹ ; Fakhroueian Z¹ ; Shahriari S² ; Khorramizadeh MR^{2, 3}
Source: Materials Science and Engineering C Published:2017

Abstract

Inherent biocompatibility and stability of zinc oxide nanoparticles (ZnO-NPs) and their biomedical potentials make them an emerging candidate for drug delivery. The aim of this study was to develop and assess a simple procedure for surface functionalization of ZnO-NPs by 3-mercaptopropionic acid (MPA) for water-soluble curcumin delivery. Carboxyl-terminated ZnO nanoparticles were successfully made using ZnCl2 and NaOH in the presence of MPA. The functional groups were activated by 1,1′-carbonyldiimidazole (CDI) and the curcumin bonding was carried out at room temperature for 24 h. The core-shell nanocomposite had a significant better solubility versus free curcumin, as characterized by XRD, FTIR, UV–Vis spectrophotometry, DLS, and TEM, p < 0.005. In addition, MTT cytotoxicity assessment on MDA-MB-231 breast cancer cells revealed a drop of IC50 values from 5 μg/mL to 3.3 μg/mL for free curcumin and ZnO-MPA-curcumin complex, respectively. This result showed an augmented cancer-inhibitory effect of nanoconjugate complex. In conclusion, the presented improved solubility and elevated functionality of novel ZnO-MPA-curcumin nanoformula is promising, and could be considered for new therapeutic endeavors. © 2017 Elsevier B.V.