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Micrornas in Breast Cancer: Roles, Functions, and Mechanism of Actions Publisher Pubmed



Abolghasemi M1, 2 ; Tehrani SS3, 4 ; Yousefi T1, 2 ; Karimian A1, 2 ; Mahmoodpoor A5 ; Ghamari A5 ; Jadidiniaragh F6 ; Yousefi M6 ; Kafil HS13 ; Bastami M6 ; Edalati M14 ; Eyvazi S7 ; Naghizadeh M3, 4 ; Targhazeh N8 Show All Authors
Authors
  1. Abolghasemi M1, 2
  2. Tehrani SS3, 4
  3. Yousefi T1, 2
  4. Karimian A1, 2
  5. Mahmoodpoor A5
  6. Ghamari A5
  7. Jadidiniaragh F6
  8. Yousefi M6
  9. Kafil HS13
  10. Bastami M6
  11. Edalati M14
  12. Eyvazi S7
  13. Naghizadeh M3, 4
  14. Targhazeh N8
  15. Yousefi B9
  16. Safa A10
  17. Majidinia M11
  18. Rameshknia V9, 12

Source: Journal of Cellular Physiology Published:2020


Abstract

Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor-κ B, phosphoinositide-3-kinase/Akt, and extracellular-signal-regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer. © 2019 Wiley Periodicals, Inc.
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