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Cardio-Pulmonary Histopathology With Clinical Correlations of Deceased Patients With Covid-19: A Case Series in Tehran, Iran Publisher Pubmed



Soleimanmeigooni S1 ; Yaghmayee R2 ; Mohammadi S3 ; Ahmadi M4 ; Sakhabakhsh M5 ; Hamidifarahani R4 ; Hazrati E6 ; Jazayeri SM7 ; Fotoohi M2 ; Motemaveleh A8 ; Doulatabadifarahani V9 ; Shahmohamadi F10 ; Kazemigalougahi MH11 ; Asgari A4 Show All Authors
Authors
  1. Soleimanmeigooni S1
  2. Yaghmayee R2
  3. Mohammadi S3
  4. Ahmadi M4
  5. Sakhabakhsh M5
  6. Hamidifarahani R4
  7. Hazrati E6
  8. Jazayeri SM7
  9. Fotoohi M2
  10. Motemaveleh A8
  11. Doulatabadifarahani V9
  12. Shahmohamadi F10
  13. Kazemigalougahi MH11
  14. Asgari A4
  15. Aminianfar M4
  16. Darvishi M4
  17. Mohajeriiravani M12
  18. Gholizadeh O7

Source: Archives of Iranian Medicine Published:2023


Abstract

Background: SARS-CoV-2 may affect vital organs. The present study investigated the histopathology of pulmonary and cardiac tissues with clinical correlation in deceased patients with COVID-19. Methods: We obtained pulmonary and cardiac tissues from 30 deceased patients with COVID-19 in Tehran, Iran, from January to May 2021. Sampling was performed through a percutaneous needle biopsy. After slide preparation, two expert pathologists studied them. We assessed the correlation between clinical and pathological data by Fisher's exact test. Results: The mean age of the patients was 73.8 ± 13.4 years, and the male-to-female ratio was 23/7. The most common underlying disease was hypertension (HTN) in 25 patients (83%). Fifty-five tissue samples were achieved, including 28 pulmonary and 27 cardiac samples. Our results showed that all patients (100%) developed diffuse alveolar damage (DAD), and 26 (93%) developed hyaline membrane formation. The most common phase of DAD was the exudative-proliferative phase in 16 (57.1%). Three cardiac samples (11%) revealed myocarditis, and seven (26%) showed cardiomyocyte hypertrophy. In univariate analysis using Fischer's exact test, myocarditis had significant relationships with C-reactive protein (CRP) levels higher than 80 mg/dL (P = 0.008) and elevated cardiac troponin levels higher than two-fold (P = 0.01). Conclusion: COVID-19 can affect the major vital organs. However, only myocarditis had a significant relationship with the circulating levels of inflammatory factors. © 2023 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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