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Research Paper: The Effects of 3,4-Methylenedioxy-Methamphetamine on Neurogenesis in the Hippocampus of Male Rats Publisher



Asl SS1 ; Moravej FG1 ; Kowsari G2 ; Farhadi MH3 ; Pourhaydar B4 ; Hamidabadi HG5 ; Mehdizadeh M6
Authors

Source: Basic and Clinical Neuroscience Published:2020


Abstract

Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses. Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related. Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells. © 2020 Iran University of Medical Sciences. All rights reserved.
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