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Palladium-Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives With K4[Fe(Cn)6] by C–H Bond Activation Publisher



Kianmehr E1 ; Faghih N1 ; Tanbakouchian A1 ; Mahdavi M2
Authors

Source: European Journal of Organic Chemistry Published:2016


Abstract

A practical, versatile, and efficient method for the palladium-catalyzed direct cyanation of readily available acetanilides with K4[Fe(CN)6] as a safe cyanating agent through C–H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N-(2-cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim