Transcriptional Regulation of B Cell Class-Switch Recombination: The Role in Development of Noninfectious Complications Publisher Pubmed



Vlachiotis S¹ ; Abolhassani H^{1, 2}
Source: Expert Review of Clinical Immunology Published:2022

Abstract

Introduction: The process of immunoglobulin class switch recombination (CSR) occurs in secondary lymphoid organs. This highly regulated process is essential for the development of different antibody isotype maturation and long-life memory/plasma cell generation. Patients with impaired CSR present heterogeneous noninfectious complications. Areas covered: We provide an overview of recent advancements in the tight regulation of B cells before and during the CSR at different levels of cytokine stimulations, intracellular signaling, transcription-factor activation, gene transcription, and epigenetic controls. Expert opinion: Besides recurrent infections which result from the lack of production of class-switched immunoglobulins, intrinsic B cell signaling pathways and regulatory component defects have distinct roles in other immune-related clinical manifestations including autoimmunity, atopy, lymphoproliferation, and cancer. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.