Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Ctrp1 in Liver Disease Publisher Pubmed



Shabani P1 ; Emamgholipour S1 ; Doosti M1
Authors

Source: Advances in Clinical Chemistry Published:2017


Abstract

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabolic disorders, presence of common molecular mediators contributing to pathomechanism of these disorders is expected. Mounting evidence has demonstrated important role of adipokines in the context of NAFLD. Adipokines produced by different tissues, mainly adipose, modulate numerous pathways including glucose and fatty acid metabolism and inflammation. CTRPs (C1q/TNF-related proteins) are a recently identified family of adipokines in which adiponectin is the most well-known ones. CTRP1 is a member of this family which has captured attention in recent years. CTRP1 enhances glucose and fatty acid oxidation, improves insulin sensitivity, attenuates plaque formation, and increases aldosterone production. Hence, various roles in metabolic pathways can link CTRP1 to NAFLD pathogenesis. © 2017 Elsevier Inc.
Related Docs
View other Related Docs
1. The C1q/Tnf-Related Proteins (Ctrps) in Pathogenesis of Obesity-Related Metabolic Disorders: Focus on Type 2 Diabetes and Cardiovascular Diseases, Life Sciences (2020)
2. Association of C1q/Tnf-Related Protein-3 (Ctrp3) and Ctrp13 Serum Levels With Coronary Artery Disease in Subjects With and Without Type 2 Diabetes Mellitus, PLoS ONE (2016)
3. The Circulating Levels of Ctrp1 and Ctrp5 Are Associated With Obesity Indices and Carotid Intima-Media Thickness (Cimt) Value in Patients With Type 2 Diabetes: A Preliminary Study, Diabetology and Metabolic Syndrome (2021)
Experts (# of related papers)
View all Related Experts
Solaleh Emamgholipour (8)
Hossein Poustchi (4)
Other Related Docs
4. Circulating Level of Ctrp1 in Patients With Nonalcoholic Fatty Liver Disease (Nafld): Is It Through Insulin Resistance?, PLoS ONE (2015)
5. The Circulating Levels of Complement-Clq/Tnf-Related Protein 13 (Ctrp13) in Patients With Type 2 Diabetes and Its Association With Insulin Resistance, Clinical Laboratory (2017)
6. The Circulating Ctrp13 in Type 2 Diabetes and Non-Alcoholic Fatty Liver Patients, PLoS ONE (2016)
7. Circulating Levels of C1q/Tnf-Α-Related Protein 6 (Ctrp6) in Polycystic Ovary Syndrome, IUBMB Life (2020)
8. The Association of Circulating Levels of Complement-C1q Tnf-Related Protein 5 (Ctrp5) With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes: A Case-Control Study, Diabetology and Metabolic Syndrome (2015)
9. Decreased Serum Levels of Ctrp12/Adipolin in Patients With Coronary Artery Disease in Relation to Inflammatory Cytokines and Insulin Resistance, Cytokine (2019)
10. Evaluation of Changing the Pattern of Ctrp5 and Inflammatory Markers Levels in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus, Archives of Physiology and Biochemistry (2022)
11. Increased Mrna Expression of Ctrp3 and Ctrp9 in Adipose Tissue From Obese Women: Is It Linked to Obesity-Related Parameters and Mrna Expression of Inflammatory Cytokines?, Reports of Biochemistry and Molecular Biology (2020)
12. Lower Circulating Levels of Ctrp12 and Ctrp13 in Polycystic Ovarian Syndrome: Irrespective of Obesity, PLoS ONE (2018)
13. Serum C1q/Tnf-Related Protein-2 (Ctrp2) Levels Are Associated With Coronary Artery Disease, Archives of Medical Research (2020)
14. The Gene Expression of Ctrp12 But Not Ctrp13 Is Upregulated in Both Visceral and Subcutaneous Adipose Tissue of Obese Subjects, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
15. Circulating Ctrp5 in Rheumatoid Arthritis: An Exploratory Biomarker Study, BMC Rheumatology (2022)
16. Circulating Levels of C1q/Tnf-Α‐Related Protein 6 (Ctrp6) in Coronary Artery Disease and Its Correlation With Inflammatory Markers, Journal of Diabetes and Metabolic Disorders (2024)
17. Higher Serum Level of Ctrp15 in Patients With Coronary Artery Disease Is Associated With Disease Severity, Body Mass Index and Insulin Resistance, Archives of Physiology and Biochemistry (2022)
18. Association of Circulating Ctrp9 With Soluble Adhesion Molecules and Inflammatory Markers in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease, PLoS ONE (2018)
19. C1q/Tnf-Related Protein-1: Potential Biomarker for Early Diagnosis of Autism Spectrum Disorder, International Journal of Immunopathology and Pharmacology (2022)
20. Serum Levels of C1q/Tnf-Related Protein-3 in Inflammatory Bowel Disease Patients and Its Inverse Association With Inflammatory Cytokines and Insulin Resistance, IUBMB Life (2020)