The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)

The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231) Publisher Pubmed

Eivazy P^{1, 2} ; Atyabi F⁴ ; Jadidiniaragh F⁵ ; Aghebati Maleki L² ; Miahipour A⁶ ; Abdolalizadeh J¹ ; Yousefi M^{2, 3}

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017

Abstract

High-mobility group protein two (HMGA2), a nonhistone nuclear-binding protein and its downregulators; vimentin, matrix metallopeptidase-9 (MMP-9), and E-cadherin are shown to contribute to tumor progression and metastasis. Thus, in this study, we checked simultaneous delivery of HMGA-2 siRNA and the anticancer drug doxorubicin to enhance the anticancer treatment effects. For this purpose, we used MTT assay and real-time polymerase chain reaction (RT-PCR). Our results showed that dual delivery of Dox and HMGA-2 siRNA by trimethyl chitosan (TMC) significantly inhibited breast cancer cells growth. Additionally, the delivery of siRNA significantly silenced HMGA-2, vimentin, and MMP9 mRNAs, but led to overexpression of E-cadherin mRNA. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Fatemeh Atyabi (7)

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Style	Citing Format
MLA	Eivazy P, et al.. "The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)." Artificial Cells# Nanomedicine and Biotechnology, vol. 45, no. 5, 2017, pp. 889-896.
APA	Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, Yousefi M (2017). The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231). Artificial Cells# Nanomedicine and Biotechnology, 45(5), 889-896.
Chicago	Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, Yousefi M. "The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)." Artificial Cells# Nanomedicine and Biotechnology 45, no. 5 (2017): 889-896.
Harvard	Eivazy P et al. (2017) 'The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)', Artificial Cells# Nanomedicine and Biotechnology, 45(5), pp. 889-896.
Vancouver	Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, et al.. The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231). Artificial Cells# Nanomedicine and Biotechnology. 2017;45(5):889-896.
BibTex	@article{ author = {Eivazy P and Atyabi F and Jadidiniaragh F and Aghebati Maleki L and Miahipour A and Abdolalizadeh J and Yousefi M}, title = {The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {45}, number = {5}, pages = {889-896}, year = {2017} }
RIS	TY - JOUR AU - Eivazy P AU - Atyabi F AU - Jadidiniaragh F AU - Aghebati Maleki L AU - Miahipour A AU - Abdolalizadeh J AU - Yousefi M TI - The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231) JO - Artificial Cells# Nanomedicine and Biotechnology VL - 45 IS - 5 SP - 889 EP - 896 PY - 2017 ER -

Style

Citing Format

MLA

Eivazy P, et al.. "The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)." Artificial Cells# Nanomedicine and Biotechnology, vol. 45, no. 5, 2017, pp. 889-896.

APA

Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, Yousefi M (2017). The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231). Artificial Cells# Nanomedicine and Biotechnology, 45(5), 889-896.

Chicago

Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, Yousefi M. "The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)." Artificial Cells# Nanomedicine and Biotechnology 45, no. 5 (2017): 889-896.

Harvard

Eivazy P et al. (2017) 'The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)', Artificial Cells# Nanomedicine and Biotechnology, 45(5), pp. 889-896.

Vancouver

Eivazy P, Atyabi F, Jadidiniaragh F, Aghebati Maleki L, Miahipour A, Abdolalizadeh J, et al.. The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231). Artificial Cells# Nanomedicine and Biotechnology. 2017;45(5):889-896.

BibTex

@article{ author = {Eivazy P and Atyabi F and Jadidiniaragh F and Aghebati Maleki L and Miahipour A and Abdolalizadeh J and Yousefi M}, title = {The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {45}, number = {5}, pages = {889-896}, year = {2017} }

RIS

TY - JOUR
AU - Eivazy P
AU - Atyabi F
AU - Jadidiniaragh F
AU - Aghebati Maleki L
AU - Miahipour A
AU - Abdolalizadeh J
AU - Yousefi M
TI - The Impact of the Codelivery of Drug-Sirna by Trimethyl Chitosan Nanoparticles on the Efficacy of Chemotherapy for Metastatic Breast Cancer Cell Line (Mda-Mb-231)
JO - Artificial Cells# Nanomedicine and Biotechnology
VL - 45
IS - 5
SP - 889
EP - 896
PY - 2017
ER -

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Abstract