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Activation and Deactivation of 5-Ht1 Receptor of Accumbens Shell Area Does Not Alter Acpa-Induced Aversive Memory Deficit in Male Rat Pubmed



Keramatinojedehsadat M1 ; Oryan S2 ; Zarrindast MR3, 4 ; Babapour V5
Authors

Source: Archives of Iranian Medicine Published:2017


Abstract

Background: Some studies have indicated a close relation between serotonergic and cannabinoidergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male Wistar rats. Methodology: Bilateral guide cannulae were implanted to allow microinjection of ACPA, CP94253 Hcl (5-HT1 receptor agonist agonist) orGR127935 Hcl (5-HT1 receptorantagonist). Results: Post-test intra-Acb shell of ACPA (0.002 µg/rat), CP94253 (0.5 and 5 ng/rat) and GR127935 (5 ng/rat) increased the percentage of open-arms time (%OAT) in the EPM task compared to the control group, indicating aversive memory deficit. Moreover, concurrent microinjection of the subthreshold dose of CP94253 and GR127935 into Acb shell did not alter open-arms exploratory behavior induced by intra-Acb shell of ACPA on the retest day. Conclusion: Our data suggests that Acb shell 5-HT1 receptor does not affect aversive memory deficit induced by ACPA in the Acb shell. © 2017, Academy of Medical Sciences of I.R. Iran. All rights reserved.
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