Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia

Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia Publisher

Mohtavinejad N¹ ; Bitarafanrajabi A² ; Shafiee Ardestani M¹ ; Darbandiazar A³ ; Khalaj A⁴ ; Ghodrati A⁴ ; Asadi M⁴ ; Amanlou M⁴

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2020

Abstract

Myocardial ischemia and infarction represent a major health burden worldwide, but their immediate diagnosis can reduce mortality and healthcare costs. Pyroglutamate helix B surface peptide (pHBSP) derived from erythropoietin have shown tissue-protective effects in the ischemic situation by binding to erythropoietin receptor–Beta common receptors)EPOR–βcR(. This research aimed to synthesize and biologically evaluate p-NH2-Bn-DTPA-(Lys-Dabcyl6,Phe7)-pHBSP for cardiac ischemia imaging. Radiolabeling yielded more than 97%, and radiolabeled peptide showed significant binding affinity to H9c2 hypoxic cells (p < 0.001). A considerable accumulation of 99mTc-p-NH2-Bn-DTPA-(Lys-Dabcyl6,Phe7)-pHBSP was detected in the ischemic region by biodistribution study and SPECT/CT scintigraphy (3.84 ID/g% at 30 min). © 2020, Akademiai Kiado, Budapest, Hungary.

Related Docs

View other Related Docs

1. Synthesis and Evaluation of 99Mtc-Dota-Ara-290 As Potential Spect Tracer for Targeting Cardiac Ischemic Region, Iranian Journal of Basic Medical Sciences (2021)

2. Technetium-99 M-Pegylated Dendrimer-G2-(Dabcyle-Lys6,Phe7)-Phbsp: A Novel Nano-Radiotracer for Molecular and Early Detecting of Cardiac Ischemic Region, Bioorganic Chemistry (2020)

3. Up-Regulation of Nitric Oxide Synthases by Erythropoietin Alone or in Conjunction With Ischemic Preconditioning in Ischemia Reperfusion Injury of Rat Kidneys, General Physiology and Biophysics (2017)

Experts (# of related papers)

View all Related Experts

Omid Sabzevari (2)

Mehdi Shafee Ardestani (2)

Style	Citing Format
MLA	Mohtavinejad N, et al.. "Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia." Journal of Radioanalytical and Nuclear Chemistry, vol. 324, no. 2, 2020, pp. 635-646.
APA	Mohtavinejad N, Bitarafanrajabi A, Shafiee Ardestani M, Darbandiazar A, Khalaj A, Ghodrati A, Asadi M, Amanlou M (2020). Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia. Journal of Radioanalytical and Nuclear Chemistry, 324(2), 635-646.
Chicago	Mohtavinejad N, Bitarafanrajabi A, Shafiee Ardestani M, Darbandiazar A, Khalaj A, Ghodrati A, Asadi M, Amanlou M. "Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia." Journal of Radioanalytical and Nuclear Chemistry 324, no. 2 (2020): 635-646.
Harvard	Mohtavinejad N et al. (2020) 'Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia', Journal of Radioanalytical and Nuclear Chemistry, 324(2), pp. 635-646.
Vancouver	Mohtavinejad N, Bitarafanrajabi A, Shafiee Ardestani M, Darbandiazar A, Khalaj A, Ghodrati A, et al.. Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia. Journal of Radioanalytical and Nuclear Chemistry. 2020;324(2):635-646.
BibTex	@article{ author = {Mohtavinejad N and Bitarafanrajabi A and Shafiee Ardestani M and Darbandiazar A and Khalaj A and Ghodrati A and Asadi M and Amanlou M}, title = {Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {324}, number = {2}, pages = {635-646}, year = {2020} }
RIS	TY - JOUR AU - Mohtavinejad N AU - Bitarafanrajabi A AU - Shafiee Ardestani M AU - Darbandiazar A AU - Khalaj A AU - Ghodrati A AU - Asadi M AU - Amanlou M TI - Synthesis and Labeling of P-Nh2-Bn-Dtpa-(Dabcyl-Lys6,Phe7)-Phbsp With 99Mtc As a Radiopeptide Scintigraphic Agent to Detect Cardiac Ischemia JO - Journal of Radioanalytical and Nuclear Chemistry VL - 324 IS - 2 SP - 635 EP - 646 PY - 2020 ER -

Science Communicator Platform

Authors

Abstract