Radiation-Induced Valvulopathy



Seilani P¹ ; Alizadeasl A² ; Fumani HK³ ; Moradian M⁴ ; Ghorbanpoor M⁵ ; Parhizgar SE⁵
Source: Iranian Heart Journal Published:2022

Abstract

Cardiovascular disease and cancer are the 2 leading causes of morbidity and mortality in the world. Radiation to the mediastinum is a key component of treatment for numerous neoplasms, including Hodgkin’s lymphoma and breast cancer. Improvements in oncological treatments have increased the number of survivors, some of whom may suffer from adverse cardiovascular effects due to radiation therapy.1, 2 The delayed detrimental cardiovascular effects of such radiotherapy protocols have been recognized more recently, largely due to the latency of presentation.3 Because of the increased life expectancy of these patients, healthcare providers are witnessing an increasing number of long-term side effects of these treatments. Mediastinal radiotherapy is known to cause valvular disease, pericarditis, coronary artery disease, and cardiomyopathy.4 We herein describe a patient who developed radiation-induced valvulopathy with the typical presentation of radiation-induced heart disease 8 years after a left-sided mastectomy and receiving chemotherapy and radiotherapy for breast cancer. © 2022, Iranian Heart Association. All rights reserved.