Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The New Frontier of Jak Inhibitors: Significant Therapeutic Response to Tofacitinib in a Patient With Granulomatous Reaction to Filler in the Buttocks Publisher Pubmed



Mansouri P1 ; Farshi S1
Authors

Source: Journal of Cosmetic Dermatology Published:2024


Abstract

Background: Recent research has demonstrated that Janus Kinase (JAK) inhibitors can be effective in treating refractory granulomatous diseases. Case Presentation: We report the case of a 50-year-old woman who developed a granulomatous reaction following a filler injection in her buttocks. Management: The patient was treated with tofacitinib, and after 1 year of therapy, the stiffness and swelling resolved without any side effects. Conclusion: Tofacitinib appears to be a viable option for the treatment of granulomatous reactions to fillers. © 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
Related Docs
View other Related Docs
1. Emerging Role of Janus Kinase Inhibitors in Treating Granuloma Annulare: A Clinical, Narrative Review of Efficacy and Safety, International Journal of Dermatology (2025)
2. Janus Kinase (Jak) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature, Journal of Dermatological Treatment (2017)
3. Jak Inhibitors in Solid Organ Transplantation, Journal of Clinical Pharmacology (2023)
Experts (# of related papers)
View all Related Experts
Alireza Firooz (1)
Vahidehsadat Azhari (1)
Other Related Docs
4. A Case of Severe Generalized Granuloma Annulare Responding Well to Tofacitinib, Case Reports in Dermatological Medicine (2025)
5. A Systematic Review of Janus Kinase Inhibitors and Spleen Tyrosine Kinase Inhibitors for Hidradenitis Suppurativa Treatment, International Immunopharmacology (2024)
6. Janus-Kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature, Journal of Pediatrics Review (2023)
7. A Literature Review on Janus Kinase (Jak) Inhibitors for the Treatment of Immunobullous Disorders, International Immunopharmacology (2022)
8. Efficacy and Safety of Tofacitinib in the Treatment of Adults With Lichen Planopilaris: A Randomized Placebo-Controlled Trial, International Immunopharmacology (2025)