Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer

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Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer Publisher

Jahanbanesfahlan R¹ ; Massoumi B² ; Abbasian M² ; Farnudiyanhabibi A^{3, 4} ; Samadian H⁵ ; Rezaei A⁵ ; Derakhshankhah H⁶ ; Jaymand M⁵

Source: Polymer-Plastics Technology and Materials Published:2020

Abstract

Novel thermal- and pH-responsive hollow nanocapsules (HNCaps) were fabricated through the grafting of a thiol-end capped PNIPAAm-b-PAA by thiol-ene “click” reaction onto PMMA HNCaps. The lowest critical solution temperature (LCST) of the fabricated HNCaps was obtained as 38–40°C. The fabricated nanosystem was loaded with doxorubicin hydrochloride (Dox), and its drug loading and encapsulation efficiencies were obtained as 62 and 53%, respectively. The in vitro stimuli-responsive drug release behavior of the fabricated nanomedicine was investigated extensively. The anticancer activity of the drug-loaded HNCaps was evaluated using MTT assay against MCF7 cells. The results exhibited excellent potential of nanosystem as a drug delivery system (DDS) for cancer chemotherapy. © 2020 Taylor & Francis.

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Style	Citing Format
MLA	Jahanbanesfahlan R, et al.. "Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer." Polymer-Plastics Technology and Materials, vol. 59, no. 13, 2020, pp. 1492-1504.
APA	Jahanbanesfahlan R, Massoumi B, Abbasian M, Farnudiyanhabibi A, Samadian H, Rezaei A, Derakhshankhah H, Jaymand M (2020). Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer. Polymer-Plastics Technology and Materials, 59(13), 1492-1504.
Chicago	Jahanbanesfahlan R, Massoumi B, Abbasian M, Farnudiyanhabibi A, Samadian H, Rezaei A, Derakhshankhah H, Jaymand M. "Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer." Polymer-Plastics Technology and Materials 59, no. 13 (2020): 1492-1504.
Harvard	Jahanbanesfahlan R et al. (2020) 'Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer', Polymer-Plastics Technology and Materials, 59(13), pp. 1492-1504.
Vancouver	Jahanbanesfahlan R, Massoumi B, Abbasian M, Farnudiyanhabibi A, Samadian H, Rezaei A, et al.. Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer. Polymer-Plastics Technology and Materials. 2020;59(13):1492-1504.
BibTex	@article{ author = {Jahanbanesfahlan R and Massoumi B and Abbasian M and Farnudiyanhabibi A and Samadian H and Rezaei A and Derakhshankhah H and Jaymand M}, title = {Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer}, journal = {Polymer-Plastics Technology and Materials}, volume = {59}, number = {13}, pages = {1492-1504}, year = {2020} }
RIS	TY - JOUR AU - Jahanbanesfahlan R AU - Massoumi B AU - Abbasian M AU - Farnudiyanhabibi A AU - Samadian H AU - Rezaei A AU - Derakhshankhah H AU - Jaymand M TI - Dual Stimuli-Responsive Polymeric Hollow Nanocapsules As “Smart” Drug Delivery System Against Cancer JO - Polymer-Plastics Technology and Materials VL - 59 IS - 13 SP - 1492 EP - 1504 PY - 2020 ER -

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