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A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms Publisher Pubmed



Golmohammadi M1 ; Elmaghraby DA2 ; Ramirezcoronel AA3, 4, 5, 6 ; Rakhimov N7 ; Mohammed SS8 ; Romeroparra RM9 ; Jawad MA10 ; Zamanian MY11, 12 ; Soltani A13 ; Taheri N14 ; Kianifar F15 ; Vousooghi N16
Authors

Source: Fundamental and Clinical Pharmacology Published:2023


Abstract

Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC. © 2023 Societe Francaise de Pharmacologie et de Therapeutique.
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